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Title: Lmtk2  
Author: World Heritage Encyclopedia
Language: English
Subject: Tyrosine kinase
Publisher: World Heritage Encyclopedia


Lemur tyrosine kinase 2
RNA expression pattern

Serine/threonine-protein kinase LMTK2 also known as Lemur tyrosine kinase 2 (LMTK2) is an enzyme that in humans is encoded by the LMTK2 gene.[1][2]


The LMTK2 enzyme belongs to both the protein kinase and the tyrosine kinase families. It contains N-terminus transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosphorylates other proteins, and is itself also phosphorylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.[2]


LMTK2 has been shown to interact with PPP1CA,[3] Cyclin-dependent kinase 5[4] and PPP1R2.[3]


Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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