World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0005719287
Reproduction Date:

Title: Lomustine  
Author: World Heritage Encyclopedia
Language: English
Subject: List of drugs: Cb-Ce, Nitrosourea, Semustine, Carmustine, List of MeSH codes (D02)
Collection: Alkylating Antineoplastic Agents, Iarc Group 2A Carcinogens, Nitrosamines, Nitrosoureas, Organochlorides, Ureas
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Trade names CeeNU
  • D
Legal status
  • (Prescription only)
Routes of
Pharmacokinetic data
Bioavailability ~100%
Protein binding 50%
Metabolism hepatic
Biological half-life 16–48 hours
CAS Registry Number  Y
ATC code L01
PubChem CID:
DrugBank  Y
ChemSpider  Y
Synonyms 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
Chemical data
Formula C9H16ClN3O2
Molecular mass 233.695 g/mol
Physical data
Melting point 90 °C (194 °F)

Lomustine (CCNU), marketed under the name CeeNU in U.S.) is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid-soluble drug, and thus crosses the blood-brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).


External links

  • CeeNu (lomustine) Capsules data sheet published by the FDA
  • Lomustine at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Patient information at
  • DDB 29525

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.