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Loxoprofen

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Loxoprofen

Loxoprofen
Systematic (IUPAC) name
(RS)-2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
Clinical data
AHFS/Drugs.com
Legal status
Routes of
administration
Oral, transdermal
Pharmacokinetic data
Protein binding 97%
Metabolism Hepatic glucuronidation
Biological half-life 75 minutes
Excretion Renal
Identifiers
CAS Registry Number  N
ATC code M01
PubChem CID:
ChemSpider  Y
UNII  Y
KEGG  Y
ChEBI  N
ChEMBL  Y
Chemical data
Formula C15H18O3
Molecular mass 246.302 g/mol
304.314 g/mol (sodium salt)
 N   

Loxoprofen (INN) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is marketed in Brazil, Mexico and Japan by Sankyo as its sodium salt, loxoprofen sodium, under the trade name Loxonin, Argentina as Oxeno and in India as Loxomac. It is available in these countries for oral administration, and a transdermal preparation was approved for sale in Japan on January 2006.[1]

Contents

  • Pharmacokinetics 1
  • Mechanism of action 2
  • Interactions 3
  • References 4

Pharmacokinetics

Loxoprofen is a prodrug. It is quickly converted to its active trans-alcohol metabolite following oral administration, and reaches its peak plasma concentration within 30 to 50 minutes.

Mechanism of action

As most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid.

Interactions

Loxoprofen should not be administered at the same time as second-generation quinolone antibiotics such as ciprofloxacin and norfloxacin, as it increases their inhibition of GABA and this may cause seizures.[2] It may also increase the plasma concentration of warfarin, methotrexate, sulfonylurea derivatives and lithium salts, so care should be taken when loxoprofen is administered to patients taking any of these drugs.[2]

References

  1. ^  
  2. ^ a b "LOXONIN - Bula do Medicamento [Label Information]" (in Português). Centralx. 2007. Retrieved 2007-04-19. 
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