World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0005667526
Reproduction Date:

Title: Loxoprofen  
Author: World Heritage Encyclopedia
Language: English
Subject: Miroprofen, Polmacoxib, Felbinac, Magnesium salicylate, Nabumetone
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
(RS)-2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
Clinical data
Legal status
Routes of
Oral, transdermal
Pharmacokinetic data
Protein binding 97%
Metabolism Hepatic glucuronidation
Biological half-life 75 minutes
Excretion Renal
CAS Registry Number  N
ATC code M01
PubChem CID:
ChemSpider  Y
Chemical data
Formula C15H18O3
Molecular mass 246.302 g/mol
304.314 g/mol (sodium salt)

Loxoprofen (INN) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is marketed in Brazil, Mexico and Japan by Sankyo as its sodium salt, loxoprofen sodium, under the trade name Loxonin, Argentina as Oxeno and in India as Loxomac. It is available in these countries for oral administration, and a transdermal preparation was approved for sale in Japan on January 2006.[1]


  • Pharmacokinetics 1
  • Mechanism of action 2
  • Interactions 3
  • References 4


Loxoprofen is a prodrug. It is quickly converted to its active trans-alcohol metabolite following oral administration, and reaches its peak plasma concentration within 30 to 50 minutes.

Mechanism of action

As most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid.


Loxoprofen should not be administered at the same time as second-generation quinolone antibiotics such as ciprofloxacin and norfloxacin, as it increases their inhibition of GABA and this may cause seizures.[2] It may also increase the plasma concentration of warfarin, methotrexate, sulfonylurea derivatives and lithium salts, so care should be taken when loxoprofen is administered to patients taking any of these drugs.[2]


  1. ^  
  2. ^ a b "LOXONIN - Bula do Medicamento [Label Information]" (in Português). Centralx. 2007. Retrieved 2007-04-19. 
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.