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Luebering-Rapoport pathway

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Title: Luebering-Rapoport pathway  
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Subject: Respiratory physiology, Organophosphates, Physiology
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Luebering-Rapoport pathway

In biochemistry, the Luebering-Rapoport pathway (also called the Luebering-Rapoport shunt) is a metabolic pathway in mature erythrocytes involving the formation of 2,3-bisphosphoglycerate (2,3-BPG), which regulates oxygen release from hemoglobin and delivery to tissues. 2,3-BPG, the reaction product of the Luebering-Rapoport pathway was first described and isolated in 1925 by the Austrian biochemist Samuel Mitja Rapoport and his technical assistant Janet Luebering.[1]

Through the Luebering-Rapoport pathway bisphosphoglycerate phosphatase. The concentration of 2,3-BPG varies inversely with the hydrogen-ion concentration [H+], which is inhibitory to catalytic action of bisphosphoglyceromutase.


  1. ^ R. Juel: 2,3-Diphosphoglycerate: its role in health and disease. In: CRC Critical Reviews in Clinical Laboratory Sciences. 10(2)/1979. CRC Press, S. 113–146, ISSN 0590-8191

External links

  • UniProt: Bisphosphoglycerate mutase - Homo sapiens (Human) UniProt-Information about bisphosphoglycerate mutase
  • A live model of the effect of changing 2,3-bisphosphoglycerate on the oxyhaemoglobin saturation curve
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