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Lymphotoxin beta receptor

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Lymphotoxin beta receptor

"LTBR" redirects here. For the airport in Turkey with that ICAO code, see Yenişehir Airport.
Lymphotoxin beta receptor (TNFR superfamily, member 3)
Available structures
PDB Ortholog search: RCSB
Identifiers
LTBR Gene
RNA expression pattern

Lymphotoxin beta receptor is a receptor for lymphotoxin which in humans is encoded by the LTBR gene.[2][3][4]

Function

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis.[2]

Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. LTBR is also essential for development and organization of the secondary lymphoid organs and chemokine release.[5]

Structure

The Ramachandran plots show that 64.6% of all residues were in a favored region. This structure was found using X-ray diffraction. The resolution is 3.50 angstroms. The alpha and beta angles are 90 degrees while the gamma angle is 120 degrees.[6]

Interactions

Lymphotoxin beta receptor has been shown to interact with Diablo homolog[7] and TRAF3.[8][9][10]

References

Further reading

External links

  • Medical Subject Headings (MeSH)
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