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Title: Mcm2  
Author: World Heritage Encyclopedia
Language: English
Subject: Minichromosome maintenance, ORC1, Replication protein A1, MCM5, MCM3
Publisher: World Heritage Encyclopedia


Minichromosome maintenance complex component 2
Symbols  ; BM28; CCNL1; CDCL1; D3S3194; MITOTIN; cdc19
External IDs GeneCards:
EC number
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.[1][2] The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.[3]

See also


MCM2 has been shown to interact with Replication protein A1,[4] AKAP8,[5] MCM5,[4][6] MCM6,[4][7][8][9][10] MCM7,[4][8][9][10][11] ORC1L,[4] ORC2L,[4] ORC4L,[4] ORC5L,[4] MCM4,[4][8][9][12] MCM3[4] and Cell division cycle 7-related protein kinase.[4]


  1. ^ Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (Jul 1991). "Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle". Biochem Biophys Res Commun 177 (1): 395–400.  
  2. ^ Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (Jan 1994). "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21". Cytogenet Cell Genet 65 (4): 276–7.  
  3. ^ "Entrez Gene: MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)". 
  4. ^ a b c d e f g h i j k Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28.  
  5. ^ Eide, Turid; Taskén Kristin A; Carlson Cathrine; Williams Gareth; Jahnsen Tore; Taskén Kjetil; Collas Philippe (Jul 2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. (United States) 278 (29): 26750–6.  
  6. ^ DaFonseca, C J; Shu F; Zhang J J (Mar 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma".  
  7. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network".  
  8. ^ a b c Yabuta, Norikazu; Kajimura Naoko; Mayanagi Kouta; Sato Michio; Gotow Takahito; Uchiyama Yasuo; Ishimi Yukio; Nojima Hiroshi (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells (England) 8 (5): 413–21.  
  9. ^ a b c You, Z; Komamura Y; Ishimi Y (Dec 1999). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. (UNITED STATES) 19 (12): 8003–15.  
  10. ^ a b You, Zhiying; Ishimi Yukio; Masai Hisao; Hanaoka Fumio (Nov 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. (United States) 277 (45): 42471–9.  
  11. ^ Fujita, M; Kiyono T; Hayashi Y; Ishibashi M (Apr 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35.  
  12. ^ Ishimi, Y; Ichinose S; Omori A; Sato K; Kimura H (Sep 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. (UNITED STATES) 271 (39): 24115–22.  

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