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MKL/megakaryoblastic leukemia 1 is a protein that in humans is encoded by the MKL1 gene.[1][2][3][4] The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.[4]
Dna, Eukaryote, Rna, Chromosome, Gene expression
Protein structure, X-ray crystallography, Nuclear magnetic resonance spectroscopy of proteins, Bioinformatics, Protein Data Bank (file format)
MySQL, Database, UCSC Genome Browser, Gene, Drosophila melanogaster
Acute myeloid leukemia, Leukemia, Myeloproliferative disease, Down syndrome, Chromosome 22 (human)
Chromosome 22 (human), Intersex, Pathology, Igh@, Mosaic (genetics)
Chromosome 22 (human), Igh@, Embryology, Ring chromosome, Epilepsy
Chromosome 22 (human), Pathology, Igh@, Aneuploidy, Klinefelter syndrome