Megakaryocyte–erythroid progenitor cell

Lineage. Captions in Polish, but "MEP" visible at bottom center.

The megakaryocyte–erythroid progenitor cell (or MEP, or hMEP to specify human^[1]) is a cell that gives rise to megakaryocytes and erythrocytes.^[2]^[3]

It is derived from the common myeloid progenitor.^[4]

References

^ Mori Y, Iwasaki H, Kohno K, et al. (January 2009). "Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor". J. Exp. Med. 206 (1): 183–93.

^ Megakaryocyte-erythroid progenitor cells at the US National Library of Medicine Medical Subject Headings (MeSH)
^ "Blood – On the origins of megakaryocytes". Retrieved 2009-03-04.
^ Edvardsson L, Dykes J, Olofsson T (May 2006). "Isolation and characterization of human myeloid progenitor populations – TpoR as discriminator between common myeloid and megakaryocyte/erythroid progenitors". Exp. Hematol. 34 (5): 599–609.

Myeloid physiology

Hematopoiesis

Myelopoiesis
(CFU-GEMM)

CFU-GM

Granulopoiesis Myeloblast Promyelocyte Myelocyte Metamyelocyte Band cell

Monocytopoiesis Monoblast Promonocyte

MEP

Thrombopoiesis Megakaryoblast Promegakaryocyte

Erythropoiesis Proerythroblast Normoblast Reticulocyte

General

Extramedullary hematopoiesis

Hemostasis

Other

Erythrocyte aggregation

: MYL

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drug (//), ,

Myeloid lineage - Blood (WBC and RBC)

CFU-M:
Monocytes/
MPS

Macrophages	Histiocytes Kupffer cells Alveolar macrophage Microglia Osteoclasts Epithelioid cells giant cells Langhans giant cells, Foreign-body giant cell Touton giant cells

CFU-DL	Dendritic cells Langerhans cell

Common

Myelomonocyte

CFU-Baso

Granulocytes
- Basophil

CFU-Eos

Granulocytes
- Eosinophil

MEP

CFU-Meg	Megakaryoblast (* primitive Kacheshmarova's cell) Megakaryocyte (Kacheshmarova's cell) Platelets

CFU-E	Reticulocyte Normoblast

CFU-Mast

Mast cell precursors

Noncellular

Plasma

: MYL

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Categories

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Megakaryocyte–erythroid progenitor cell