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Title: Mepivacaine  
Author: World Heritage Encyclopedia
Language: English
Subject: Anesthetic, ATC code N01, Local anesthetic, Sodium channel blocker, Cocaine
Collection: Anilides, Local Anesthetics, Piperidines
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
(RS)-N-(2,6-dimethylphenyl)- 1-methyl-piperidine-2-carboxamide
Clinical data
  • C, use w/ caution, may cause fetal bradycardia
CAS Registry Number  Y
ATC code N01
PubChem CID:
DrugBank  Y
ChemSpider  Y
Chemical data
Formula C15H22N2O
Molecular mass 246.348 g/mol

Mepivacaine is a local anesthetic[1] of the amide type. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine) and is marketed under various trade names including Carbocaine and Polocaine.

Mepivacaine became available in the United States in the 1960s.

Mepivacaine is used in any infiltration and regional anesthesia.

It is supplied as the hydrochloride salt of the racemate.[2]


  1. ^ Porto GG, Vasconcelos BC, Gomes AC, Albert D (January 2007). "Evaluation of lidocaine and mepivacaine for inferior third molar surgery" (PDF). Med Oral Patol Oral Cir Bucal 12 (1): E60–4.  
  2. ^ Burm AG, Cohen IM, van Kleef JW, Vletter AA, Olieman W, Groen K (January 1997). "Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers". Anesth. Analg. 84 (1): 85–9.  

External links

  • Mepivacaine at RxList

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