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Mucoepidermoid carcinoma

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Title: Mucoepidermoid carcinoma  
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Subject: Salivary gland neoplasm, Warthin's tumor, Head and neck cancer, Epithelial-myoepithelial carcinoma of the lung, Human cytomegalovirus
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Mucoepidermoid carcinoma

Mucoepidermoid carcinoma
Micrograph of a mucoepidermoid carcinoma. FNA specimen. Pap stain.
Classification and external resources
ICD-O M8430/3
OMIM 607536
MeSH C04.557.470.200.025.340

Mucoepidermoid carcinoma is the most common type of

  • -489684982 at GPnotebook
  • Overview at usc.edu
  • Slide at jhu.edu

External links

  1. ^ Elsevier Article Locator
  2. ^ Modern Pathology – Primary Mucoepidermoid Carcinoma and Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid Gland: A Report of Nine Cases
  3. ^ Melnick, M.; Sedghizadeh, P. P.; Allen, C. M.; Jaskoll, T. (2012). "Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: Cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship". Experimental and Molecular Pathology 92 (1): 118–125.  
  4. ^ Isayeva T, Said-Al-Naief N, Ren Z, Li R, Gnepp D, Brandwein-Gensler M (2012) Salivary mucoepidermoid carcinoma: Demonstration of transcriptionally active human papillomavirus 16/18. Head Neck Pathol

References

Additional images

Generally, there is a good prognosis for low-grade tumors, and a poor prognosis for high-grade tumors.

Prognosis

A possible association with papillomavirus has been reported.[4]

Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 PMID 16444749.

Molecular biology

This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

Histology

Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors.

Clinical Features

Occurs in adults, with peak incidence from 20–40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research.[3]

Epidemiology

Contents

  • Epidemiology 1
  • Clinical Features 2
  • Histology 3
  • Molecular biology 4
  • Prognosis 5
  • Additional images 6
  • References 7
  • External links 8

Mucicarmine staining is one stain used by pathologist for detection.[2]

and thyroid. [1]

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