World Library  
Flag as Inappropriate
Email this Article

Mucoepidermoid carcinoma

Article Id: WHEBN0004876377
Reproduction Date:

Title: Mucoepidermoid carcinoma  
Author: World Heritage Encyclopedia
Language: English
Subject: Salivary gland neoplasm, Warthin's tumor, Head and neck cancer, Epithelial-myoepithelial carcinoma of the lung, Human cytomegalovirus
Publisher: World Heritage Encyclopedia

Mucoepidermoid carcinoma

Mucoepidermoid carcinoma
Micrograph of a mucoepidermoid carcinoma. FNA specimen. Pap stain.
Classification and external resources
ICD-O M8430/3
OMIM 607536
MeSH C04.557.470.200.025.340

Mucoepidermoid carcinoma is the most common type of

  • -489684982 at GPnotebook
  • Overview at
  • Slide at

External links

  1. ^ Elsevier Article Locator
  2. ^ Modern Pathology – Primary Mucoepidermoid Carcinoma and Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid Gland: A Report of Nine Cases
  3. ^ Melnick, M.; Sedghizadeh, P. P.; Allen, C. M.; Jaskoll, T. (2012). "Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: Cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship". Experimental and Molecular Pathology 92 (1): 118–125.  
  4. ^ Isayeva T, Said-Al-Naief N, Ren Z, Li R, Gnepp D, Brandwein-Gensler M (2012) Salivary mucoepidermoid carcinoma: Demonstration of transcriptionally active human papillomavirus 16/18. Head Neck Pathol


Additional images

Generally, there is a good prognosis for low-grade tumors, and a poor prognosis for high-grade tumors.


A possible association with papillomavirus has been reported.[4]

Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 PMID 16444749.

Molecular biology

This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells.


Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors.

Clinical Features

Occurs in adults, with peak incidence from 20–40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research.[3]



  • Epidemiology 1
  • Clinical Features 2
  • Histology 3
  • Molecular biology 4
  • Prognosis 5
  • Additional images 6
  • References 7
  • External links 8

Mucicarmine staining is one stain used by pathologist for detection.[2]

and thyroid. [1]

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.