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Muramyl dipeptide

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Muramyl dipeptide

Muramyl dipeptide
Identifiers
CAS number 53678-77-6
PubChem 11620162
ChemSpider 9794910 YesY
MeSH Muramyl+dipeptide
Jmol-3D images Image 1
Properties
Molecular formula C19H32N4O11
Molar mass 492.47758
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Muramyl dipeptide is a peptidoglycan constituent of both Gram positive and Gram negative bacteria. It is composed of N-acetylmuramic acid linked by its lactic acid moiety to the N-terminus of an L-alanine D-isoglutamine dipeptide.[1]

It can be recognized by the immune system as a PAMP (pathogen associated molecular pattern)and activate the NALP3 inflammasome which in turn leads to cytokine activation, especially IL-1α and IL-1β. [2]

See also

References


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