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Nfatc3

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Nfatc3

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; NFAT4; NFATX
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.[1][2] The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.[2]

See also

References

  1. ^ Hoey T, Sun YL, Williamson K, Xu X (Jun 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity 2 (5): 461–72.  
  2. ^ a b "Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3". 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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