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Nfyb

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Title: Nfyb  
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Subject: CCAAT/enhancer binding protein zeta, NFYC, Transcription factors, NeuroD, EMX homeogene
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Nfyb

Nuclear transcription factor Y, beta

PDB rendering based on 1n1j.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CBF-A; CBF-B; HAP3; NF-YB
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.[1][2] The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.[3]

Interactions

NFYB has been shown to interact with CCAAT/enhancer binding protein zeta,[4] CNTN2,[5] TATA binding protein[6] and Myc.[7]

References

  1. ^ Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D (Mar 1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics 11 (3): 630–4.  
  2. ^ Maity SN, de Crombrugghe B (Jun 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends Biochem Sci 23 (5): 174–8.  
  3. ^ "Entrez Gene: NFYB nuclear transcription factor Y, beta". 
  4. ^ Imbriano, C; Bolognese F; Gurtner A; Piaggio G; Mantovani R (Jul 2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. (United States) 276 (28): 26332–9.  
  5. ^ Pise-Masison, C A; Dittmer J; Clemens K E; Brady J N (Mar 1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Mol. Cell. Biol. (UNITED STATES) 17 (3): 1236–43.  
  6. ^ Bellorini, M; Lee D K; Dantonel J C; Zemzoumi K; Roeder R G; Tora L; Mantovani R (Jun 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. (ENGLAND) 25 (11): 2174–81.  
  7. ^ Izumi, H; Molander C; Penn L Z; Ishisaki A; Kohno K; Funa K (Apr 2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". J. Cell. Sci. (England) 114 (Pt 8): 1533–44.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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