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Title: Nkx3-1  
Author: World Heritage Encyclopedia
Language: English
Subject: NKX-homeodomain factor, Homeobox, Transcription factors, NeuroD, EMX homeogene
Publisher: World Heritage Encyclopedia


NK3 homeobox 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; BAPX2; NKX3; NKX3.1; NKX3A
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Homeobox protein Nkx-3.1 is a protein that in humans is encoded by the NKX3-1 gene.[1] The homeodomain-containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3A protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.[supplied by OMIM][2]


NKX3-1 has been shown to interact with SPDEF.[3]

The stability of NKX3-1 protein has been shown to be regulated by phosphorylation. [4]


  1. ^ He WW, Sciavolino PJ, Wing J, Augustus M, Hudson P, Meissner PS, Curtis RT, Shell BK, Bostwick DG, Tindall DJ, Gelmann EP, Abate-Shen C, Carter KC (September 1997). "A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer". Genomics 43 (1): 69–77.  
  2. ^ "Entrez Gene: NKX3-1 NK3 transcription factor related, locus 1 (Drosophila)". 
  3. ^ Chen, Hui; Nandi Asit K; Li Xiang; Bieberich Charles J (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. (United States) 62 (2): 338–40.  
  4. ^ Padmanabhan, Achuth; Gosc Eliza; Bieberich Charles J (May 2013). "Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells.". J Cellular Biochemistry (United States) 114 (5): 1050–7.

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