Nandrolone Decanoate

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Nandrolone (19-nortestosterone) is an anabolic steroid. Nandrolone is most commonly sold commercially as its decanoate ester (Deca-Durabolin) and less commonly as a phenylpropionate ester (Durabolin). Nandrolone decanoate is used in the treatment of osteoporosis in postmenopausal women (though now not recommended) at a dose of 50 mg every three weeks. It is also used for some aplastic anemias.

Metabolism

The positive effects of the drug include muscle growth, appetite stimulation and increased red blood cell production and bone density. Clinical studies have shown it to be effective in treating anaemia, osteoporosis and some forms of neoplasia including breast cancer, and also acts as a progestin-based contraceptive. For these reasons, in the United States nandrolone received FDA approval in 1983.

Because nandrolone is not broken down into DHT, the deleterious effects common to most anabolic steroids on the scalp, skin, and prostate are lessened to a degree; but is rather broken down to the much weaker androgen dihydronandrolone. The lack of alkylation on the 17α-carbon drastically reduces the drug's liver toxicity. Estrogenic effects resulting from reaction with aromatase are also reduced due to lessened enzyme interaction,[1] but effects such as gynaecomastia and reduced libido still occur in larger doses because of other mechanisms. Other side-effects of abuse can include erectile dysfunction and cardiovascular damage, as well as several ailments resulting from the drug's effect of lowering levels of luteinizing hormone through negative feedback. Erectile dysfunction is attributed to the weaker action of dihydronandrolone in the penis since dihydrotestosterone is a known sexual modulator.

Detection method

Nandrolone use is directly detectable in hair or indirectly detectable in urine by testing for the presence of 19-norandrosterone, a metabolite. The International Olympic Committee has set a limit of 2.0 μg/L of 19-norandrosterone in urine as the upper limit,[2] beyond which an athlete is suspected of doping. In the largest nandrolone study performed on 621 athletes at the 1998 Nagano Olympic Games, no athlete tested over 0.4 μg/L. 19-Norandrosterone was identified as a trace contaminant in commercial preparations of androstenedione, which until 2004 was available without a prescription as a dietary supplement in the U.S.[3][4][5][6]

A number of nandrolone cases in athletics occurred in 1999, which included high profile athletes such as Merlene Ottey, Dieter Baumann and Linford Christie.[7] However, the following year the detection method for nandrolone at the time was proved to be faulty. Mark Richardson, a British Olympic relay runner who tested positive for the substance, gave a significant amount of urine samples in a controlled environment and delivered a positive test for the drug, demonstrating that false positives could occur, which led to an overhaul of his competitive ban.[8]

Heavy consumption of the essential amino acid lysine (as indicated in the treatment of cold sores) has allegedly shown false positives in some and was cited by American shotputter C.J. Hunter as the reason for his positive test, though in 2004 he admitted to a federal grand jury that he had injected nandrolone.[9] A possible cause of incorrect urine test results is the presence of metabolites from other anabolic steroids, though modern urinalysis can usually determine the exact steroid used by analyzing the ratio of the two remaining nandrolone metabolites. As a result of the numerous overturned verdicts, the testing procedure was reviewed by UK Sport. On October 5, 2007, five-time gold medalist for track and field Marion Jones admitted to use of the drug, and was sentenced to six months in jail for lying to a federal grand jury in 2000.[10]


Mass spectrometry is also used to detect small samples of nandrolone in urine samples, as it has a unique molar mass.

Publicized cases

  • In November 1994, South Africa's Jamie Bloem was the first rugby league footballer to test positive for nandrolone. He was banned for two years.[11][12][13]
  • Petr Korda tested positive for nandrolone after his 1998 Wimbledon quarter final match against Tim Henman. Korda was banned from tennis for one year from September 1999.[14]
  • Roger Clemens, who was a member of the 2000 World Series winning New York Yankees, was reported to have been injected with nandrolone (Deca-Durabolin) by major league strength coach Brian McNamee during the 2000 baseball season.[15]
  • Barry Bonds is reported to have begun a regime of banned steroids and human growth hormones following his disappointment with insufficient acclaim for his past natural baseball achievements. In the 1999 spring training camp his trainer readily admitted to a Bonds' teammate that Bonds was doping the steroid Deca-Durabolin.[16]
  • UFC Hall of Famer Royce Gracie tested positive for nandrolone after defeating his longtime rival Kazushi Sakuraba at K-1 Dynamite!! USA in 2007, he was fined $2,500 and suspended for the remainder of his license.[17]
  • Shoaib Akhtar, a Pakistani cricketer, was given a two-year ban in 2006 for testing positive for nandrolone. Shoaib was sent back to Pakistan and missed out competing for the Champions Trophy. The verdict, however, was overturned by a three-man tribunal a month later.[18]
  • Sean Sherk, former UFC Lightweight Champion, tested positive for nandrolone following his title defence to Hermes Franca at UFC 73. Sherk passed a lie detector test claiming that he did not knowingly take steroids but the UFC still stripped Sherk of the lightweight title.[19]
  • Linford Christie, a British sprinter and 1992 Olympic gold medalist, tested positive for nandrolone in 1999.[20]
  • Former Maryland Terrapin and NBA player Juan Dixon tested positive for use of this drug in 2009, which earned him a suspension by the International Basketball Federation.[21]
  • In September 2010, Baltimore Orioles minor league shortstop Alfredo Zambrano received a 50-game suspension for the 2011 season as a result of testing positive for metabolites of nandrolone.[22]
  • Indian athlete Rani Yadav and Sri Lankan boxer Manju Wanniarachchi tested positive for nandrolone at the 2010 Commonwealth Games.[23]
  • British tennis player Greg Rusedski tested positive for nandrolone in January 2004,[24] but was cleared of the charges in a hearing on 10 March 2004.[25]

See also

  • 19-Norprogesterone

References

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