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Naptumomab estafenatox

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Title: Naptumomab estafenatox  
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Subject: List of therapeutic monoclonal antibodies, Nacolomab tafenatox
Publisher: World Heritage Encyclopedia

Naptumomab estafenatox

Naptumomab estafenatox (ABR-217620) is a drug being developed for the treatment of various types of cancer like non-small cell lung carcinoma[1] and renal cell carcinoma.[2]

Mechanism of action

Chemically, it is a fusion protein consisting of the antigen-binding fragment (Fab) of a monoclonal antibody with the superantigen staphylococcal enterotoxin E (SEA/E-120, "estafenatox").[3] The Fab binds to 5T4, an antigen expressed by various tumor cells, and the superantigen induces an immune response by activating T lymphocytes.

See also


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