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Neurophysin I

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Title: Neurophysin I  
Author: World Heritage Encyclopedia
Language: English
Subject: Neurophysins, Oxytocin, Herring bodies, Iron-binding proteins, Retinol binding protein
Collection: Integral Membrane Proteins
Publisher: World Heritage Encyclopedia

Neurophysin I

Oxytocin/neurophysin I prepropeptide
Symbols  ; OT; OT-NPI; OXT-NPI
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Neurophysin I is a carrier protein with a size of 10 KDa and containing 90 to 97 aminoacids that is a cleavage product (formed by splitting of a compound molecule into a simpler one) of preprooxyphysin.[1] It is a neurohypophysial hormone that is transported in vesicles with oxytocin, the other cleavage product, along axons, from magnocellular neurons of the hypothalamus to the posterior lobe of the pituitary. Although it is stored in secretory vesicles with oxytocin and released with oxytocin, its biological action is unclear.


The amino acid sequence of Neurophysin I is:

NH2 - Ala - Ala - Pro - Asp - Leu - Asp - Val - Arg - Lys - Cys - Leu - Pro - Cys - Gly - Pro - Gly - Gly - Lys - Gly - Arg - Cys - Phe - Gly - Pro - Asn - Ile - Cys - Cys - Ala - Glu - Glu - Leu - Gly - Cys - Phe - Val - Gly - Thr - Ala - Glu - Ala - Leu - Arg - Cys - Gln - Glu - Glu - Asn - Tyr - Leu - Pro - Ser - Pro - Cys - Gln - Ser - Gly - Gln - Lys - Ala - Cys - Gly - Ser - Gly - Gly - Arg - Cys - Ala - Val - Leu - Gly - Leu - Cys - Cys - Ser - Pro - Asp - Gly - Cys - His - Ala - Asp - Pro - Ala - Cys - Asp - Ala - Glu - Ala - Thr - Phe - Ser - Gln – Arg - OH

(Disulfide bridge: 10-54; 13-27; 21-44; 28-34; 61-73; 67-85; 74-79)


Neurophysins are carrier proteins for oxytocin and vasopressin (ADH). Oxytocin and vasopressin are carried by unique neurophysins from their site of production in the cell bodies of the paraventricular and supraoptic nuclei to their site of release in the axon terminals of the posterior pituitary.


  1. ^ Rao VV, Löffler C, Battey J, Hansmann I (1992). "The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization". Cytogenet. Cell Genet. 61 (4): 271–3.  
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