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Neurophysin I

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Title: Neurophysin I  
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Subject: Neurophysins, Oxytocin, Herring bodies, Iron-binding proteins, Retinol binding protein
Collection: Integral Membrane Proteins
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Neurophysin I

Oxytocin/neurophysin I prepropeptide
Identifiers
Symbols  ; OT; OT-NPI; OXT-NPI
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Neurophysin I is a carrier protein with a size of 10 KDa and containing 90 to 97 aminoacids that is a cleavage product (formed by splitting of a compound molecule into a simpler one) of preprooxyphysin.[1] It is a neurohypophysial hormone that is transported in vesicles with oxytocin, the other cleavage product, along axons, from magnocellular neurons of the hypothalamus to the posterior lobe of the pituitary. Although it is stored in secretory vesicles with oxytocin and released with oxytocin, its biological action is unclear.

Structure

The amino acid sequence of Neurophysin I is:

NH2 - Ala - Ala - Pro - Asp - Leu - Asp - Val - Arg - Lys - Cys - Leu - Pro - Cys - Gly - Pro - Gly - Gly - Lys - Gly - Arg - Cys - Phe - Gly - Pro - Asn - Ile - Cys - Cys - Ala - Glu - Glu - Leu - Gly - Cys - Phe - Val - Gly - Thr - Ala - Glu - Ala - Leu - Arg - Cys - Gln - Glu - Glu - Asn - Tyr - Leu - Pro - Ser - Pro - Cys - Gln - Ser - Gly - Gln - Lys - Ala - Cys - Gly - Ser - Gly - Gly - Arg - Cys - Ala - Val - Leu - Gly - Leu - Cys - Cys - Ser - Pro - Asp - Gly - Cys - His - Ala - Asp - Pro - Ala - Cys - Asp - Ala - Glu - Ala - Thr - Phe - Ser - Gln – Arg - OH

(Disulfide bridge: 10-54; 13-27; 21-44; 28-34; 61-73; 67-85; 74-79)


Function

Neurophysins are carrier proteins for oxytocin and vasopressin (ADH). Oxytocin and vasopressin are carried by unique neurophysins from their site of production in the cell bodies of the paraventricular and supraoptic nuclei to their site of release in the axon terminals of the posterior pituitary.

References

  1. ^ Rao VV, Löffler C, Battey J, Hansmann I (1992). "The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization". Cytogenet. Cell Genet. 61 (4): 271–3.  
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