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Title: Norsteroid  
Author: World Heritage Encyclopedia
Language: English
Subject: Antiestrogen, Endometrin, Algestone, Quingestanol acetate, Promegestone
Publisher: World Heritage Encyclopedia


Norsteroids (nor-, L. norma, from "normal" in chemistry, indicating carbon removal) are a structural class of steroids that have had an atom or atoms (typically carbon) removed, biosynthetically or synthetically, from positions of branching off of rings or side chains (e.g., removal of methyl groups), or from within rings of the steroid ring system.[1][2] For instance, 19-norsteroids (e.g., 19-norprogesterone) constitute an important class of natural and synthetic steroids derived by removal of the methyl group of the natural product progesterone; the equivalent change between testosterone and 19-nortestosterone (nandrolone) is illustrated below.


Norsteroid examples include: norpregnene (from pregnatriene), quinestrol, 19-norprogesterone (from a progesterone), Nomegestrol acetate,[3] 19-nortestosterone (from a testosterone), and norethisterone acetate.[3]

progesterone 19-norprogesterone
testosterone nortestosterone (nandrolone)


  1. ^ International Union of Pure and Applied Chemistry (IUPAC), 1999, "RF-4.1 Removal of Skeletal Atoms," in "RF-4. Skeletal Modifications" in Revised Section F: Natural Products and Related Compounds (IUPAC Recommendations 1999), see [2], accessed 20 May 2014. See also IUPAC, 1976, "Nomenclature of Organic Chemistry: Section F - Natural Products and Related Compounds, Recommendations 1976", IUPAC Information Bulletin Appendices on Tentative Nomenclature, Symbols, Units, and Standards, No. 53, December, 1976, also in Eur. J. Biochem. 1978, 86, 1-8.
  2. ^ Norsteroids at the US National Library of Medicine Medical Subject Headings (MeSH)
  3. ^ a b Couzinet B, Young J, Brailly S, Chanson P, Thomas JL, Schaison G (December 1996). "The antigonadotropic activity of progestins (19-nortestosterone and 19-norprogesterone derivatives) is not mediated through the androgen receptor". J. Clin. Endocrinol. Metab. 81 (12): 4218–23.  

External links

  • Bricout V, Wright F (2004). "Update on nandrolone and norsteroids: how endogenous or xenobiotic are these substances?". Eur J Appl Physiol 92 (1-2): 1–12.  

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