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Ophthalmic acid

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Title: Ophthalmic acid  
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Subject: Alpha-Aminobutyric acid, S-Nitrosoglutathione, Peptides
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Ophthalmic acid

Ophthalmic acid[1]
Stereo, skeletal formula of ophthalmic acid
IUPAC name
ChemSpider  YesY
Jmol-3D images Image
Molar mass 289.29 g·mol−1
Appearance Colorless crystals
Related compounds
Related alkanoic acids
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N  (: YesY/N?)

Ophthalmic acid, also known as ophthalmate (chemically L-γ-glutamyl-L-α-aminobutyrylglycine), is a tripeptide analogue of glutathione in which the cysteine group is replaced by L-2-aminobutyrate. It was first discovered and isolated from calf lens.[2]


Recent studies have shown that the ophthalmate can be biologically synthesized from 2-amino butyric acid through consecutive reactions with gamma-glutamylcysteine synthetase and glutathione synthetase. So the ophthalmic acid could be used as a biomarker in oxidative stress where the depletion of glutathione takes place.[3]


  1. ^ Ophthalmic acid
  2. ^ Waley SG; Biochem. J. 64, 715 (1956).
  3. ^

See also

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