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Pbx1

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Title: Pbx1  
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Pbx1

Pre-B-cell leukemia homeobox 1

Cartoon diagram of a HOXB1–PBX1 heterodimer (violet) binding a DNA fragment (blue). Rendering based on PDB 1b72.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; DKFZp686B09108; MGC126627
External IDs ChEMBL: GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.[1]


Contents

  • Interactions 1
  • References 2
  • Further reading 3
  • External links 4

Interactions

PBX1 has been shown to interact with HOXB1,[2][3] MEIS1[4][5][6] and HOXB7.[7]

References

  1. ^ "Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1". 
  2. ^ Berthelsen, J; Zappavigna V; Ferretti E; Mavilio F; Blasi F (Mar 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. (ENGLAND) 17 (5): 1434–45.  
  3. ^ Piper, D E; Batchelor A H; Chang C P; Cleary M L; Wolberger C (Feb 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell (UNITED STATES) 96 (4): 587–97.  
  4. ^ Shen, W F; Rozenfeld S; Kwong A; Köm ves L G; Lawrence H J; Largman C (Apr 1999). "HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells". Mol. Cell. Biol. (UNITED STATES) 19 (4): 3051–61.  
  5. ^ Shanmugam, K; Green N C; Rambaldi I; Saragovi H U; Featherstone M S (Nov 1999). "PBX and MEIS as Non-DNA-Binding Partners in Trimeric Complexes with HOX Proteins". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7577–88.  
  6. ^ Jacobs, Y; Schnabel C A; Cleary M L (Jul 1999). "Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity". Mol. Cell. Biol. (UNITED STATES) 19 (7): 5134–42.  
  7. ^ Chang, C P; Shen W F; Rozenfeld S; Lawrence H J; Largman C; Cleary M L (Mar 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. (UNITED STATES) 9 (6): 663–74.  

Further reading

  • Sanyal M, Tung JW (2007). "B-cell development fails in the absence of the Pbx1 proto-oncogene". Blood. 109 (10): 4191–9.  
  • Hui H, Perfetti R (2002). "Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood". Eur. J. Endocrinol. 146 (2): 129–41.  
  • Hunger SP, Galili N, Carroll AJ, et al. (1991). "The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias". Blood 77 (4): 687–93.  
  • Monica K, Galili N, Nourse J, et al. (1991). "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1". Mol. Cell. Biol. 11 (12): 6149–57.  
  • Nourse J, Mellentin JD, Galili N, et al. (1990). "Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor". Cell 60 (4): 535–45.  
  • Kamps MP, Murre C, Sun XH, Baltimore D (1990). "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL". Cell 60 (4): 547–55.  
  • Lu Q, Wright DD, Kamps MP (1994). "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation". Mol. Cell. Biol. 14 (6): 3938–48.  
  • Van Dijk MA, Voorhoeve PM, Murre C (1993). "Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6061–5.  
  • Lu Q, Kamps MP (1996). "Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex". Mol. Cell. Biol. 16 (4): 1632–40.  
  • Berthelsen J, Zappavigna V, Mavilio F, Blasi F (1998). "Prep1, a novel functional partner of Pbx proteins". EMBO J. 17 (5): 1423–33.  
  • Berthelsen J, Zappavigna V, Ferretti E, et al. (1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. 17 (5): 1434–45.  
  • Piper DE, Batchelor AH, Chang CP, et al. (1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell 96 (4): 587–97.  
  • Shen WF, Rozenfeld S, Kwong A, et al. (1999). "HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells". Mol. Cell. Biol. 19 (4): 3051–61.  
  • Jacobs Y, Schnabel CA, Cleary ML (1999). "Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity". Mol. Cell. Biol. 19 (7): 5134–42.  
  • Knoepfler PS, Bergstrom DA, Uetsuki T, et al. (1999). "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1". Nucleic Acids Res. 27 (18): 3752–61.  
  • McWhirter JR, Neuteboom ST, Wancewicz EV, et al. (1999). "Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11464–9.  
  • Shanmugam K, Green NC, Rambaldi I, et al. (1999). "PBX and MEIS as Non-DNA-Binding Partners in Trimeric Complexes with HOX Proteins". Mol. Cell. Biol. 19 (11): 7577–88.  
  • Mikkola I, Bruun JA, Holm T, Johansen T (2001). "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins". J. Biol. Chem. 276 (6): 4109–18.  
  • Thameem F, Wolford JK, Bogardus C, Prochazka M (2001). "Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians". Biochim. Biophys. Acta 1518 (1–2): 215–20.  
  • Liu Y, MacDonald RJ, Swift GH (2001). "DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex". J. Biol. Chem. 276 (21): 17985–93.  
  • Mal A, Sturniolo M, Schiltz RL, et al. (2001). "A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program". EMBO J. 20 (7): 1739–53.  

External links


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