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Title: Prdm9  
Author: World Heritage Encyclopedia
Language: English
Subject: NeuroD, EMX homeogene, Nur (biology), Early growth response proteins, NOBOX
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PR domain containing 9
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; MEISETZ; MSBP3; PFM6; PRMD9; ZNF899
External IDs GeneCards:
EC number
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

PR domain[note 1] zinc finger protein 9 is a protein that in humans is encoded by the Prdm9 gene.[1] The protein has histone H3(K4) trimethyltransferase activity, a KRAB domain, and a DNA-binding domain consisting of multiple tandem C2H2 zinc finger (ZF) domains.[2] PRDM9 specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression, but does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation which plays a central role in the transcriptional activation of genes during early meiotic prophase.


PRDM9 is thought to mediate the process of meiotic homologous recombination.[3]


  1. ^ positive-regulatory domain


  1. ^ "Entrez Gene: PR domain containing 9". 
  2. ^ Thomas JH, Emerson RO, Shendure J (2009). "Extraordinary molecular evolution in the PRDM9 fertility gene". PLoS ONE 4 (12): e8505.  
  3. ^ Smagulova F, Gregoretti IV, Brick K, Khil P, Camerini-Otero RD, Petukhova GV (April 2011). "Genome-wide analysis reveals novel molecular features of mouse recombination hotspots". Nature 472 (7343): 375–8.  

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