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Title: Ptk7  
Author: World Heritage Encyclopedia
Language: English
Subject: RTK class III, Fyn-related kinase, DDR1, Leukocyte receptor tyrosine kinase, AXL receptor tyrosine kinase
Publisher: World Heritage Encyclopedia


Protein tyrosine kinase 7 (inactive)
Symbols  ; CCK-4; CCK4
External IDs GeneCards:
EC number
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Tyrosine-protein kinase-like 7 is an enzyme that in humans is encoded by the PTK7 gene.[1][2] Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene an intracellular domain with tyrosine kinase homology and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.[2]

PTK7 serves as a context-dependent signalling switch for the Wnt pathways (particularly in planar cell polarity related functions such as convergent extension and neural crest cell migration) and appears to have similar functions for Plexin and Flt-1 pathways.


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