World Library  
Flag as Inappropriate
Email this Article

Pterygium (conjunctiva)

Article Id: WHEBN0000331752
Reproduction Date:

Title: Pterygium (conjunctiva)  
Author: World Heritage Encyclopedia
Language: English
Subject: Pinguecula, Pterygium, Irvine-Gass syndrome, Iridocorneal endothelial syndrome, Sunglasses
Collection: Disorders of Conjunctiva
Publisher: World Heritage Encyclopedia

Pterygium (conjunctiva)

Pterygium (conjunctiva)
Pterygium growing onto the cornea
Classification and external resources
ICD-10 H11.0
ICD-9-CM 372.4
DiseasesDB 10916
MedlinePlus 001011
eMedicine oph/542
MeSH D011625

Pterygium (Surfer's Eye) most often refers to a benign growth of the conjunctiva. A pterygium commonly grows from the nasal side of the conjunctiva. It is usually present in the palpebral fissure. It is associated with and thought to be caused by ultraviolet-light exposure (e.g., sunlight), low humidity, and dust. The predominance of pterygia on the nasal side is possibly a result of the sun's rays passing laterally through the cornea, where it undergoes refraction and becomes focused on the limbic area. Sunlight passes unobstructed from the lateral side of the eye, focusing on the medial limbus after passing through the cornea. On the contralateral (medial) side, however, the shadow of the nose medially reduces the intensity of sunlight focused on the lateral/temporal limbus.[1]


  • Signs and symptoms 1
  • Pathology 2
  • Prevention 3
  • Treatment 4
  • See also 5
  • References 6
  • External links 7

Signs and symptoms

Symptoms of pterygium include persistent redness from smoke[1], inflammation,[2] foreign body sensation, tearing, dry and itchy eyes. In advanced cases the pterygium can affect vision[2] as it invades the cornea with the potential of obscuring the optical center of the cornea and inducing astigmatism and corneal scarring.[3][4]


Micrograph of a conjunctiva associated with prominent blood vessels (left-bottom of image) and elastotic collagen (centre of image), as may be seen in a pterygium. H&E stain.

Pterygium in the conjunctiva is characterized by elastotic degeneration of collagen (actinic elastosis[5]) and fibrovascular proliferation. It has an advancing portion called the head of the pterygium, which is connected to the main body of the pterygium by the neck. Sometimes a line of iron deposition can be seen adjacent to the head of the pterygium called Stocker's line. The location of the line can give an indication of the pattern of growth.

The exact cause is unknown, but it is associated with excessive exposure to wind, sunlight, or sand. Therefore, it is more likely to occur in populations that inhabit the areas near the equator, as well as windy locations. In addition, pterygia are twice as likely to occur in men than women. Some research also suggests a genetic predisposition due to an expression of vimentin, which indicates cellular migration by the keratoblasts embryological development, which are the cells that give rise to the layers of the cornea. Supporting this fact is the congenital pterygium, in which pterygium is seen in infants.[6] These cells also exhibit an increased P53 expression likely due to a deficit in the tumor suppressor gene. These indications give the impression of a migrating limbus because the cellular origin of the pterygium is actually initiated by the limbal epithelium.[7]

The pterygium is composed of several segments:

  • Fuchs' Patches (minute gray blemishes that disperse near the pterygium head)
  • Stocker's Line (a brownish line composed of iron deposits)
  • Hood (fibrous nonvascular portion of the pterygium)
  • Head (apex of the pterygium, typically raised and highly vascular)
  • Body (fleshy elevated portion congested with tortuous vessels)
  • Superior Edge (upper edge of the triangular or wing-shaped portion of the pterygium)
  • Inferior Edge (lower edge of the triangular or wing-shaped portion of the pterygium).


As it is associated with excessive sun or wind exposure, wearing protective sunglasses with side shields and/or wide brimmed hats and using artificial tears throughout the day may help prevent their formation or stop further growth. Surfers and other water-sport athletes should wear eye protection that blocks 100% of the UV rays from the water, as is often used by snow-sport athletes.


Pterygium removal surgery

A variety of options are available for the management of pterygium, from irradiation, to conjunctival auto-grafting or amniotic membrane transplantation, along with glue and suture application. As it is a benign growth, pterygium typically does not require surgery until it grows to such an extent that it causes visual loss or presents with acute symptoms, or pulls on the cornea, distorting vision. Some of the irritating symptoms can be addressed with artificial tears. In some patients, cosmetic or esthetic concerns may be sufficient to warrant surgical removal. However, no reliable medical treatment exists to reduce or even prevent pterygium progression. Definitive treatment is achieved only by surgical removal. Follow-up of at least a year after surgery is required to identify 97% of recurrences that will occur. (Hirst, L.W.; Sebban, A.; Chant, D.: Pterygium Recurrence Time. Ophthalmology. 101(4): 755-758, 1994) There is a new and effective treatment using Mitomycin .01% solution (Mobius makes a kit) to keep the Pterygium from recurring.

If there is recurrence after surgery or if recurrence of pterygium is thought to be vision threatening, it is possible to use strontium (90Sr) plaque therapy. 90Sr is a radioactive substance that produces beta particles, which penetrate a very short distance into the cornea at the site of the operation. It suppresses the regrowth of blood vessels that occur with return of the pterygium. The treatment requires some local anaesthetic in the eye and is best done at the time of, or on the same day as the pterygium excision.

The 90Sr plaque is a concave metal disc about 1-1.5 cm in diameter that is hollow and filled with an insoluble strontium salt. The side placed on the eye is a very thin and delicate silver film that will contain the strontium but allow the beta particles to escape. The dose of radiation to the conjunctiva is controlled by the time that the plaque is left in contact with the surface. The integrity of the plaque surfaces is paramount to prevent exposure to patients and so is wipe tested to see if radioactive matter is escaping. Obviously this test must be done very very gently.

Conjunctival auto-grafting is a surgical technique that is effective and safe procedure for pterygium removal. When the pterygium is removed, the tissue that covers the sclera known as the conjunctiva is also extracted. Auto-grafting replaces the bare sclera with conjunctival tissue that is surgically removed from the temporal healthy conjunctiva. That “self-tissue” is then transplanted to the bare sclera and is fixated using sutures, tissue adhesive, or glue adhesive.

Amniotic membrane transplantation is an effective and safe procedure for pterygium removal. Amniotic membrane transplantation offers practical alternative to conjunctival auto graft transplantation for extensive pterygium removal. Amniotic membrane transplantation is tissue that is acquired from the innermost layer of the human placenta and has been used to replace and heal damaged mucosal surfaces including successful reconstruction of the ocular surface. It has been used as a surgical material since the 1940s, and has been shown to have a strong anti-adhesive effect.[8][9] Using an amniotic graft facilitates epithelialization, and has anti-inflammatory as well as surface rejuvenation properties. Amniotic membrane transplantation can also be fixated to the sclera using sutures, or glue adhesive. [10] [11] [12] Amniotic membrane transplantation with Tisseel glue application and Mitomycin-C has shown excellent cosmetic outcomes with a surface free of redness, stitching, or patches, which makes the ocular surface suitable for vision correction surgery sooner.[13] [14] [15]

See also


  1. ^ a b Coroneo, MT (November 1993). "Pterygium as an early indicator of ultraviolet insolation: a hypothesis". Br J Ophthalmol 77 (11): 734–9.  
  2. ^ a b Kunimoto, Derek; Kunal Kanitkar; Mary Makar (2004). The Wills eye manual: office and emergency room diagnosis and treatment of eye disease. (4th ed.). Philadelphia, PA: Lippincott Williams & Wilkins. pp. 50–51.  
  3. ^ Gulani, A.C. (24 March 2005). "Extended Sun Exposure Increases Risk of Eye Pterygium". 
  4. ^ Fisher, J.P.; Trattler, W.B. (12 January 2009). "Pterygium". 
  5. ^ Klintworth, G; Cummings, T. "24; The eye and ocular adnexa". In Stacey, Mills. Sternberg's Diagnostic Surgical Pathology (5 ed.).  
  6. ^
  7. ^ Gulani, A; Dastur, YK (Jan–Mar 1995). "Simultaneous pterygium and cataract surgery.". Journal of postgraduate medicine 41 (1): 8–11.  
  8. ^ Trelford, JD; Trelford-Sauder, M (1 August 1979). "The amnion in surgery, past and present.". American journal of obstetrics and gynecology 134 (7): 833–45.  
  9. ^ Tayyar, M; Turan, R; Ayata, D (June 1993). "The use of amniotic membrane plus heparin to prevent postoperative adhesions in the rabbit.". The Tokai journal of experimental and clinical medicine 18 (1-2): 57–60.  
  10. ^ Gulani AC. Corneoplastique. Techniques in Ophthalmology 5(1): 11-20, 2007.
  11. ^ Gulani AC. “Corneoplastique”, Video Journal of Cataract and Refractive Surgery. Volume XXII. Issue 3, 2006.
  12. ^ Gulani AC. "A New Concept for Refractive Surgery", Ophthalmology Management 2006; 10 (4). 57-63.
  13. ^ Gulani AC. Vision Corrective Surgeries: Past Techniques, Present Trends and Future Technologies, North East Florida Medicine. 2007; 2 (58) 41-44.
  14. ^ Gulani AC, Holladay J, Belin M, Ahmed I. Future Technologies in LASIK- Pentacam Advanced Diagnostic for Laser Vision Surgery. In Experts Review of Ophthalmology, 2008- London
  15. ^ Gulani AC. “ Corneoplastique: Art of Laser Vision Surgery”- Corneal Refractive Surgery in Video Atlas of Ophthalmic Surgery. XXXVIII. (2) 2008

External links

  • Media related to at Wikimedia Commons
  • Facts About the Cornea and Corneal Disease The National Eye Institute (NEI)
  • Pterygium eMedicine WebMD online article on pterygium (overview, differential diagnoses & workup, treatment & medication, and follow-up)


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.