World Library  
Flag as Inappropriate
Email this Article

Reticular fiber

Article Id: WHEBN0002780130
Reproduction Date:

Title: Reticular fiber  
Author: World Heritage Encyclopedia
Language: English
Subject: Collagen, Reticular connective tissue, Loose connective tissue, Connective tissue, Structural proteins
Collection: Structural Proteins
Publisher: World Heritage Encyclopedia

Reticular fiber

A liver biopsy stained with a reticulin stain demonstrating a normal hepatic plate thickness and mild steatosis.

Reticular fibers, reticular fibres or reticulin is a type of fiber in lymphatic system.[3]


  • History 1
  • Structure 2
  • References 3
  • External links 4


The term reticulin was coined in 1892 by M. Siegfried.[4]

Today, the term reticulin or reticular fiber is restricted to referring to fibers composed of type III collagen. However, during the pre-molecular era, there was confusion in the use of the term 'reticulin', which was used to describe two structures:

  • the argyrophilic (silver staining) fibrous structures present in basement membranes
  • histologically similar fibers present in developing connective tissue.[5]

The history of the reticulin silver stain is reviewed by Puchtler et al. (1978).[6] The abstract of this paper says:

Maresch (1905) introduced Bielschowsky's silver impregnation technic for neurofibrils as a stain for reticulum fibers, but emphasized the nonspecificity of such procedures. This lack of specificity has been confirmed repeatedly. Yet, since the 1920s the definition of "reticulin" and studies of its distribution were based solely on silver impregnation technics. The chemical mechanism and specificity of this group of stains is obscure. Application of Gömöri's and Wilder's methods to human tissues showed variations of staining patterns with the fixatives and technics employed. Besides reticulum fibers, various other tissue structures, e.g. I bands of striated muscle, fibers in nervous tissues, and model substances, e.g. polysaccharides, egg white, gliadin, were also stained. Deposition of silver compounds on reticulum fibers was limited to an easily removable substance; the remaining collagen component did not bind silver. These histochemical studies indicate that silver impregnation technics for reticulum fibers have no chemical significance and cannot be considered as histochemical technics for "reticulin" or type III collagen.


Reticular fiber is composed of one or more types of very thin and delicately woven strands of type III collagen. These strands build a highly ordered cellular network and provide a supporting network. Many of these types of collagen have been combined with carbohydrate. Thus, they react with silver stains and with periodic acid-Schiff reagent but are not demonstrated with ordinary histological stains such as those using hematoxylin. The 1953 Science article mentioned above concluded that the reticular and regular collagenous materials contains the same four sugars – galactose, glucose, mannose, and fucose – but in a much greater concentration in the reticular than in the collagenous material.

In a 1993 paper, the reticular fibers of the capillary sheath and splenic cord were studied and compared in the pig spleen by transmission electron microscopy.[7] This paper attempted to reveal their components and the presence of sialic acid in the amorphous ground substance. Collagen fibrils, elastic fibers, microfibrils, nerve fibers, and smooth muscle cells were observed in the reticular fibers of the splenic cord. On the other hand, only microfibrils were recognized in the reticular fibers of the capillary sheath. The binding of LFA lectin to the splenic cord was stronger than the capillary sheath. These findings suggested that the reticular fibers of the splenic cord include multiple functional elements and might perform an important role during contraction or dilation of the spleen. On the other hand, the reticular fiber of the capillary sheath resembled the basement membrane of the capillary in its components.

Because of their affinity for silver salts, these fibers are called argyrophilic.


  1. ^ "reticular fibers" at Dorland's Medical Dictionary
  2. ^ Strum, Judy M.; Gartner, Leslie P.; Hiatt, James L. (2007). Cell biology and histology. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 83.  
  3. ^ Burkitt, H. George; Young, Barbara; Heath, John W.; Wheater, Paul R. (1993). Wheater's Functional Histology (3rd ed.). New York: Churchill Livinstone. p. 62.  
  4. ^ Siegfried, M. (1892). Habilitationsschrift. Leipzig: F.A. Brockhaus.  Cited in Glegg, R. E.; Eidinger, D.; Leblond, C. P. (1953). "Some Carbohydrate Components of Reticular Fibers". Science 118 (3073): 614–6.  
  5. ^ Jackson, D. S.; Williams, G. (1956). "Nature of Reticulin". Nature 178 (4539): 915–6.  
  6. ^ Puchtler, Holde; Waldrop, Faye Sweat (1978). "Silver impregnation methods for reticulum fibers and reticulin: A re-investigation of their origins and specifity". Histochemistry 57 (3): 177–87.  
  7. ^ Miyata, Hiroto; Abe, Mitsuo; Takehana, Kazushige; Iwasa, Kenji; Hiraga, Takeo (1993). "Electron Microscopic Studies on Reticular Fibers in the Pig Sheathed Artery and Splenic Cords". The Journal of Veterinary Medical Science 55 (5): 821–7.  

External links

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.