World Library  
Flag as Inappropriate
Email this Article

Retinoic acid receptor

Article Id: WHEBN0005880781
Reproduction Date:

Title: Retinoic acid receptor  
Author: World Heritage Encyclopedia
Language: English
Subject: Retinoid X receptor, Nuclear receptor, Retinoic acid receptor alpha, Liver X receptor, TLX
Collection: Intracellular Receptors, Transcription Factors
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Retinoic acid receptor

retinoic acid receptor alpha
Identifiers
Symbol RARA
Entrez 5914
HUGO 9864
OMIM 180240
RefSeq NM_000964
UniProt P10276
Other data
Locus Chr. 17 q21.1
retinoic acid receptor beta
Identifiers
Symbol RARB
Entrez 5915
HUGO 9865
OMIM 180220
RefSeq NM_000965
UniProt P10826
Other data
Locus Chr. 3 p24
retinoic acid receptor gamma
Identifiers
Symbol RARG
Entrez 5916
HUGO 9866
OMIM 180190
RefSeq NM_000966
UniProt P13631
Other data
Locus Chr. 12 q13

The retinoic acid receptor (RAR) is a type of nuclear receptor which can also act as a transcription factor[1] that is activated by both all-trans retinoic acid and 9-cis retinoic acid.[2] There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma, encoded by the RARA, RARB, RARG genes, respectively. Each receptor isoform has several splice variants: two- for alpha, four- for beta, and two- for gamma.

As with other type II nuclear receptors, RAR heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements known as retinoic acid response elements (RAREs) complexed with corepressor protein. Binding of agonist ligands to RAR results in dissociation of corepressor and recruitment of coactivator protein that, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.

See also

References

  1. ^ Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H (2006). "International Union of Pharmacology. LX. Retinoic acid receptors". Pharmacol Rev 58 (4): 712–25.  
  2. ^ Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P, Levin AA (1993). "Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids". Proc Natl Acad Sci USA 90 (1): 30–4.  

External links

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.