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Sgcz

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Sgcz

Sarcoglycan, zeta
Identifiers
SGCZ Gene
Orthologs
SpeciesHumanMouse

Sarcoglycan zeta also known as SGCZ is a protein which in humans is encoded by the SGCZ gene.[1]

Function

The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix.[2]

Clinical significance

Zeta-sarcoglycan is reduced in mouse models of muscular dystrophy and SGCZ is found as a component of the vascular smooth muscle sarcoglycan complex. Hence SGCZ may be important in the pathogenesis of muscular dystrophy.[1]

References

External links

  • SGCZ

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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