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Title: Sgk  
Author: World Heritage Encyclopedia
Language: English
Subject: KvLQT1, KCNE1, Phosphoinositide-dependent kinase-1
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Serum/glucocorticoid regulated kinase 1
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Serine/threonine-protein kinase SGK is a kinase subfamily that is known as being encoded by SGK1, SGK2, and SGK3 genes.[1][2]

Among the three SGK genes, SGK1 is the most intensively studied. This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by transforming growth factor-beta (TGF-beta), which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, an involvement of SGK in the development of this condition is suggested.[3]

The SGK1 kinase regulates the myo-inositol transporter during osmotic stress.[4]

Deregulated expression of SGK1 in the endometrium has been implicated in cases of infertility or recurrent miscarriage in humans, and SGK1 expression in the endometrium also affects fertility in mice.[5]


SGK has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2,[6][7] Phosphoinositide-dependent kinase-1,[6][8] Karyopherin alpha 2,[9] MAPK7,[10] and NEDD4.[11][12]

A gain-of-function mutation in


Further reading

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