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Title: Siglec7  
Author: World Heritage Encyclopedia
Language: English
Subject: CD1E, CD1A, CD109, CD153, CD320
Collection: Clusters of Differentiation
Publisher: World Heritage Encyclopedia


Sialic acid binding Ig-like lectin 7

PDB rendering based on 1nko.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; AIRM1; CD328; CDw328; D-siglec; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2; p75; p75/AIRM1
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene.[1][2] SIGLEC7 has also been designated as CD328 (cluster of differentiation 328).


  1. ^ Nicoll G, Ni J, Liu D, Klenerman P, Munday J, Dubock S, Mattei MG, Crocker PR (Dec 1999). "Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes". J Biol Chem 274 (48): 34089–95.  
  2. ^ "Entrez Gene: SIGLEC7 sialic acid binding Ig-like lectin 7". 

Further reading

  • Reif K, Buday L, Downward J, Cantrell DA (1994). "SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases.". J. Biol. Chem. 269 (19): 14081–7.  
  • Falco M, Biassoni R, Bottino C, et al. (1999). "Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells.". J. Exp. Med. 190 (6): 793–802.  
  • Ye X, Mehlen P, Rabizadeh S, et al. (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.". J. Biol. Chem. 274 (42): 30202–8.  
  • Vitale C, Romagnani C, Falco M, et al. (2000). "Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 15091–6.  
  • Angata T, Varki A (2000). "Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.". Glycobiology 10 (4): 431–8.  
  • Ito A, Handa K, Withers DA, et al. (2001). "Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression.". FEBS Lett. 498 (1): 116–20.  
  • Mingari MC, Vitale C, Romagnani C, et al. (2002). "Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors.". Adv. Exp. Med. Biol. 495: 55–61.  
  • Yousef GM, Ordon MH, Foussias G, Diamandis EP (2002). "Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes.". Gene 286 (2): 259–70.  
  • Alphey MS, Attrill H, Crocker PR, van Aalten DM (2003). "High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family.". J. Biol. Chem. 278 (5): 3372–7.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Nicoll G, Avril T, Lock K, et al. (2003). "Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms.". Eur. J. Immunol. 33 (6): 1642–8.  
  • Dimasi N, Moretta A, Moretta L, et al. (2004). "Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1.". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 2): 401–3.  
  • Ikehara Y, Ikehara SK, Paulson JC (2004). "Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9.". J. Biol. Chem. 279 (41): 43117–25.  
  • Avril T, Floyd H, Lopez F, et al. (2005). "The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells.". J. Immunol. 173 (11): 6841–9.  
  • Yamaji T, Mitsuki M, Teranishi T, Hashimoto Y (2005). "Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs.". Glycobiology 15 (7): 667–76.  
  • Attrill H, Takazawa H, Witt S, et al. (2006). "The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design.". Biochem. J. 397 (2): 271–8.  
  • Rapoport EM, Pazynina GV, Sablina MA, et al. (2006). "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides.". Biochemistry Mosc. 71 (5): 496–504.  
  • Biedermann B, Gil D, Bowen DT, Crocker PR (2007). "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors.". Leuk. Res. 31 (2): 211–20.  

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