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Sirpb1

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Title: Sirpb1  
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Subject: CD153, NKG2, CD109, IGSF2, ALCAM
Collection: Clusters of Differentiation
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Sirpb1

Signal-regulatory protein beta 1
PDB rendering based on 2d9c.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CD172b; SIRP-BETA-1
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.[1][2][3] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B). The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.[3]

Contents

  • Interactions 1
  • References 2
  • Further reading 3
  • External links 4

Interactions

SIRPB1 has been shown to interact with TYROBP.[4][5]

References

  1. ^
  2. ^
  3. ^ a b
  4. ^
  5. ^

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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