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Sodium arsenite

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Sodium arsenite

Sodium arsenite
Names
IUPAC name
sodium arsenite
Other names
sodium arsenate(III)
Identifiers
 Y
ChEBI  N
EC number 232-070-5
Jmol-3D images Image
KEGG  N
PubChem
Properties
NaAsO2
Molar mass 129.911 g/mol
Appearance white or grayish powder
hygroscopic
Density 1.87 g/cm 3
Melting point 550 °C (1,022 °F; 823 K) decomposes
156 g/100 mL
Solubility slightly soluble in alcohol
Hazards
Safety data sheet External MSDS
R-phrases R23,R25,R45
NFPA 704
0
4
0
Lethal dose or concentration (LD, LC):
LD50 (Median dose)
41 mg/kg (rat, oral)
US health exposure limits (NIOSH):
PEL (Permissible)
[1910.1018] TWA 0.010 mg/m3[1]
REL (Recommended)
Ca C 0.002 mg/m3 [15-minute][1]
Ca [5 mg/m3 (as As)][1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N  (: Y/N?)

Sodium arsenite usually refers to the sodium salt of arsenous acid. Sodium arsenite also ) Na3AsO3, called sodium ortho-arsenite.[2] The compounds are colourless solids.

Catena-arsenite chains

Contents

  • Synthesis and structure 1
  • Health Effects 2
  • Application 3
  • Safety 4
  • References 5

Synthesis and structure

A mixture of sodium meta-arsenite and sodium ortho-arsenite is produced by treating arsenic trioxide with sodium carbonate or sodium hydroxide.[3] Sodium arsenite is amorphous, typically being obtained as a powder or as a glassy mass. The compound consists of the polymer [AsO2]n
n
associated with sodium cations, Na+. The polymer backbone has the connectivity -O-As(O)-.[4]

Health Effects

Sodium arsenite can be inhaled or absorbed through the skin. Along with its known carcinogenic and teratogenic effects, contact with the substance can yield symptoms such as skin irritation, burns, itching, thickened skin, rash, loss of pigment, poor appetite, a metallic or garlic taste, stomach pain, nausea, vomiting, diarrhea, convulsions, decreased blood pressure, and headache. Severe acute poisoning may lead to nervous system damage resulting in weakness, poor coordination, or “pins and needles” sensations, eventual paralysis, and death.[5][6]

Application

It is primarily used as a pesticide, but has other uses such as hide preservative, antiseptic, dyeing, and soaps.[7]

Sodium arsenite is an appropriate chemical stressor to induce production of heat shock proteins.[8]

Safety

The LD50 (oral, mouse) is 40 mg/kg.[3]


References

  1. ^ a b c "NIOSH Pocket Guide to Chemical Hazards #0038".  
  2. ^ Greenwood, N. N.; & Earnshaw, A. (1997). Chemistry of the Elements (2nd Edn.), Oxford:Butterworth-Heinemann. ISBN 0-7506-3365-4.
  3. ^ a b Grund, S. C.; Hanusch, K.; Wolf, H. U. (2005), "Arsenic and Arsenic Compounds",  
  4. ^ Eagleton M. (2011). Concise Encyclopedia Chemistry. Walter de Gruyter.  
  5. ^ New Jersey Department of Health and Senior Services. Hazardous Substance Fact Sheet: Sodium Arsenite [2] (2013-05-01)
  6. ^ Jing J, Zheng G, Liu M, Shen X, Zhao F, Wang J, Zhang J, Huang G, Dai P, Chen Y, Chen J, Luo W, ‘’et al.’’ (2012). "Changes in the synaptic structure of hippocampal neurons and impairment of spatial memory in a rat model caused by chronic arsenite exposure". Neurotoxicology 33 (5): 1230–8.  
  7. ^ Considine G.D. (2005). Van Nostrand’s Encylcopedia of Chemistry. 14th Ed.  
  8. ^ Bhagat L, Singh VP, Dawra RK, Saluja AK, ‘’et al.’’ (2008). "Sodium arsenite induces heat shock protein 70 expression and protects against secretagogue-induced trypsinogen and NF-kappaB activation". J Cell Physiol 215 (1): 37–46.  
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