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TEC (gene)

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Title: TEC (gene)  
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Subject: RTK class III, PTK7, Fyn-related kinase, AXL receptor tyrosine kinase, DDR1
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TEC (gene)

Tec protein tyrosine kinase

PDB rendering based on 1gl5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; PSCTK4
External IDs ChEMBL: GeneCards:
EC number
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.[1][2] The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein-coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.[2]


TEC (gene) has been shown to interact with GNA12,[3] Janus kinase 2,[4][5] CD117,[6][7] Suppressor of cytokine signaling 1,[8] ARHGEF12[3] and DOK1.[6][9]


  1. ^ Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (November 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia 8 (10): 1663–72.  
  2. ^ a b "Entrez Gene: TEC tec protein tyrosine kinase". 
  3. ^ a b Suzuki, Nobuchika; Nakamura Susumu; Mano Hiroyuki; Kozasa Tohru (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF".  
  4. ^ Takahashi-Tezuka, M; Hibi M; Fujitani Y; Fukada T; Yamaguchi T; Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene (ENGLAND) 14 (19): 2273–82.  
  5. ^ Yamashita, Y; Watanabe S, Miyazato A, Ohya K i, Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H (March 1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood (UNITED STATES) 91 (5): 1496–507.  
  6. ^ a b van Dijk, T B; van Den Akker E; Amelsvoort M P; Mano H; Löwenberg B; von Lindern M (November 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood (UNITED STATES) 96 (10): 3406–13.  
  7. ^ Tang, B; Mano H; Yi T; Ihle J N (December 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Mol. Cell. Biol. (UNITED STATES) 14 (12): 8432–7.  
  8. ^ Ohya, K i; Kajigaya S; Yamashita Y; Miyazato A; Hatake K; Miura Y; Ikeda U; Shimada K; Ozawa K; Mano H (October 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". J. Biol. Chem. (UNITED STATES) 272 (43): 27178–82.  
  9. ^ Liang, Xiquan; Wisniewski David, Strife Annabel, Shivakrupa , Clarkson Bayard, Resh Marilyn D (April 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". J. Biol. Chem. (United States) 277 (16): 13732–8.  

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