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Title: Tox3  
Author: World Heritage Encyclopedia
Language: English
Subject: TOX2, TOX, Transcription factors, NeuroD, EMX homeogene
Publisher: World Heritage Encyclopedia


TOX high mobility group box family member 3
Symbol TOX3
Alt. symbols TNRC9, CAGF9
Entrez 27324
HUGO 11972
OMIM 611416
RefSeq XM_049037
UniProt O15405
Other data
Locus Chr. 16 q12.1

TOX high mobility group box family member 3, also known as TOX3, is a human gene.[1][2]

The protein encoded by this gene is a member of a subfamily of transcription factors that also includes TOX, TOX2, and TOX4 that share almost identical HMG-box DNA-binding domains which function to modify chromatin structure.[2]

Disease linkage

Mutations in the TOX3 gene are associated with an increased risk of breast cancer.[3][4][5][6]


  1. ^ "Entrez Gene: TOX high mobility group box family member 3". 
  2. ^ a b O'Flaherty E, Kaye J (April 2003). "TOX defines a conserved subfamily of HMG-box proteins". BMC Genomics 4: 13.  
  3. ^ Smid M, Wang Y, Klijn JG, Sieuwerts AM, Zhang Y, Atkins D, Martens JW, Foekens JA (May 2006). "Genes associated with breast cancer metastatic to bone". J. Clin. Oncol. 24 (15): 2261–7.  
  4. ^ Easton DF, Pooley KA, Dunning AM, et al. (June 2007). "Genome-wide association study identifies novel breast cancer susceptibility loci". Nature 447 (7148): 1087–93.  
  5. ^ Stacey SN, Manolescu A, Sulem P, et al. (July 2007). "Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer". Nat. Genet. 39 (7): 865–9.  
  6. ^ Antoniou AC, Spurdle AB, Sinilnikova OM, et al. (April 2008). "Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers". Am. J. Hum. Genet. 82 (4): 937–48.  

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