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Title: Trd@  
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Subject: Immune system, TRG@, TRA@, Fcα/μR, Polymeric immunoglobulin receptor
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T cell receptor delta locus
Symbols  ; TCRD; TCRDV1; TRD@
External IDs GeneCards:
Species Human Mouse
Entrez n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a

T cell receptor delta locus, also known as TRD@, is a human gene.[1]


  1. ^ "Entrez Gene: TRD@ T cell receptor delta locus". 

Further reading

  • Chien YH, Iwashima M, Kaplan KB, et al. (1987). "A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation.". Nature 327 (6124): 677–82.  
  • Hayes SM, Shores EW, Love PE (2003). "An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors.". Immunol. Rev. 191: 28–37.  
  • Guglielmi P, Davi F, d'Auriol L, et al. (1988). "Use of a variable alpha region to create a functional T-cell receptor delta chain.". Proc. Natl. Acad. Sci. U.S.A. 85 (15): 5634–8.  
  • Hochstenbach F, Brenner MB (1989). "T-cell receptor delta-chain can substitute for alpha to form a beta delta heterodimer.". Nature 340 (6234): 562–5.  
  • Dyer MJ (1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms.". Blood 74 (3): 1073–83.  
  • Griesinger F, Greenberg JM, Kersey JH (1989). "T cell receptor gamma and delta rearrangements in hematologic malignancies. Relationship to lymphoid differentiation.". J. Clin. Invest. 84 (2): 506–16.  
  • Loh EY, Lanier LL, Turck CW, et al. (1988). "Identification and sequence of a fourth human T cell antigen receptor chain.". Nature 330 (6148): 569–72.  
  • Bartkowiak J, Kulczyck-Wojdala D, Blonski JZ, Robak T (2002). "Molecular diversity of gammadelta T cells in peripheral blood from patients with B-cell chronic lymphocytic leukaemia.". Neoplasma 49 (2): 86–90.  
  • Oyoshi MK, Nagata H, Kimura N, et al. (2003). "Preferential expansion of Vgamma9-JgammaP/Vdelta2-Jdelta3 gammadelta T cells in nasal T-cell lymphoma and chronic active Epstein-Barr virus infection.". Am. J. Pathol. 162 (5): 1629–38.  
  • Krejci O, Prouzova Z, Horvath O, et al. (2003). "Cutting edge: TCR delta gene is frequently rearranged in adult B lymphocytes.". J. Immunol. 171 (2): 524–7.  
  • van Hagen PM, Hooijkaas H, Vd Beemd MW, et al. (2003). "T-gammadelta receptor restriction in peripheral lymphocytes of patients with Behçet's disease.". Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology 528: 267–8.  
  • Szczepanski T, van der Velden VH, Hoogeveen PG, et al. (2004). "Vdelta2-Jalpha rearrangements are frequent in precursor-B-acute lymphoblastic leukemia but rare in normal lymphoid cells". Blood 103 (10): 3798–804.  
  • De Rosa SC, Andrus JP, Perfetto SP, et al. (2004). "Ontogeny of gamma delta T cells in humans". J. Immunol. 172 (3): 1637–45.  
  • Fronková E, Krejcí O, Kalina T, et al. (2005). "Lymphoid differentiation pathways can be traced by TCR delta rearrangements". J. Immunol. 175 (4): 2495–500.  
  • Chauhan SK, Tripathy NK, Sinha N, Nityanand S (2006). "T-cell receptor repertoire of circulating gamma delta T-cells in Takayasu's arteritis". Clin. Immunol. 118 (2–3): 243–9.  
  • Joachims ML, Chain JL, Hooker SW, et al. (2006). "Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice". J. Immunol. 176 (3): 1543–52.  
  • Karrman K, Andersson A, Björgvinsdóttir H, et al. (2006). "Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia". Eur. J. Haematol. 77 (1): 27–34.  
  • Touvrey C, Borel E, Marche PN, et al. (2006). "Gene-specific signal joint modifications during V(D)J recombination of TCRAD locus genes in murine and human thymocytes". Immunobiology 211 (9): 741–51.  

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