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Title: Tshz3  
Author: World Heritage Encyclopedia
Language: English
Subject: Homeobox, NeuroD, EMX homeogene, Engrailed (gene), Nur (biology)
Publisher: World Heritage Encyclopedia


Teashirt zinc finger homeobox 3
PDB rendering based on 2dmi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; TSH3; ZNF537
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Teashirt homolog 3 is a protein that in humans is encoded by the TSHZ3 gene.[1] In mice, it is a necessary part of the neural circuitry that controls breathing. The gene is also a homolog of the Drosophila melanogaster teashirt gene, which encodes a zinc finger transcription factor important for development of the trunk.

Tshz3-knockout mice do not develop the respiratory rhythm generator (RRG) neural circuit, which is a pacemaker that produces an oscillating rhythm in the brainstem and controls autonomous breathing. The RRG neurons are present, but are abnormal. Those mice do not survive because they don't initiate breathing after birth. Tshz-3 is being studied for its relationship to infant breathing defects in humans.[2]


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