World Library  
Flag as Inappropriate
Email this Article

Tachykinin receptor


Tachykinin receptor

tachykinin receptor 1
Symbol TACR1
Alt. symbols TAC1R
Entrez 6869
HUGO 11526
OMIM 162323
RefSeq NM_001058
UniProt P25103
Other data
Locus Chr. 2 p13.1-p12
tachykinin receptor 2
Symbol TACR2
Alt. symbols TAC2R, NKNAR
Entrez 6865
HUGO 11527
OMIM 162321
RefSeq NM_001057
UniProt P21452
Other data
Locus Chr. 10 q11-q21
tachykinin receptor 3
Symbol TACR3
Entrez 6870
HUGO 11528
OMIM 162332
RefSeq NM_001059
UniProt P29371
Other data
Locus Chr. 4 q25

There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).


  • Binding 1
  • See also 2
  • References 3
  • External links 4


The genes and receptor ligands are as follows:[1]

Receptor Gene Preferred ligand
NK1 TACR1 substance P
NK2 TACR2 neurokinin A
NK3 TACR3 neurokinin B

(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

See also


  1. ^ Maggi CA (1995). "The mammalian tachykinin receptors". Gen. Pharmacol. 26 (5): 911–44.  

External links

  • "Tachykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  • Tachykinin Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.