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Trace amine-associated receptors, abbreviated TAAR and otherwise known as trace amine receptors, abbreviated TAR or TA, are a class of G protein-coupled receptors identified in 2001.[1][2][3]
TAAR1 has gained considerable interest in academic and pharmaceutical industry research as endogenous receptors for trace amines, which are non-classical metabolic derivatives of phenylalanine and tryptophan and the psychostimulants amphetamine and methamphetamine.[3][4][5][6][7][8]
In 2004 it was shown that in mammals TAAR1 is probably also a receptor for thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormones,[4] while the mouse mTAAR2 – mTAAR9 receptors are most probably olfactory receptors for volatile amines.[9][10]
The following is a list of the TAARs contained in selected animal genomes:[1][11]
Methamphetamine, Addiction, Norepinephrine, Gene expression, PubChem
Amphetamine, Methylphenidate, Cocaine, Ethanol, Norepinephrine
Amphetamine, Methamphetamine, Serotonin, Norepinephrine, Evolution
Chlorine, Bromine, Xenon, Periodic table, Astatine
Amphetamine, Methamphetamine, Iodine, 3-Iodothyronamine, Norepinephrine
Norepinephrine, Methamphetamine, Amphetamine, Dopamine, Epinephrine
Thyroid, Thyroxine, Triiodothyronine, Thyroid-stimulating hormone, Brain
Olfaction, Gene, Orphan receptor, Odor, G protein-coupled receptor