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Transcription factor II F

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Title: Transcription factor II F  
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Subject: GTF2F2, RNA polymerase II holoenzyme, NeuroD, EMX homeogene, Nur (biology)
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Transcription factor II F

general transcription factor IIF, polypeptide 1, 74kDa
Symbol GTF2F1
Alt. symbols TFIIF, BTF4, RAP74
Entrez 2962
HUGO 4652
OMIM 189968
RefSeq NM_002096
UniProt P35269
Other data
Locus Chr. 19 p13.3
general transcription factor IIF, polypeptide 2, 30kDa
Symbol GTF2F2
Alt. symbols TFIIF, BTF4, RAP30
Entrez 2963
HUGO 4653
OMIM 189969
RefSeq NM_004128
UniProt P13984
Other data
Locus Chr. 13 q14
general transcription factor IIF, polypeptide 2-like
Symbol GTF2F2L
Alt. symbols TFIIF
Entrez 2964
HUGO 4654
RefSeq NG_003013
Other data
Locus Chr. 4 q31.22

Transcription factor IIF (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1][2][3]

Transcription Factor IIF is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes.[4][5][6]

TFIIF binds to RNA PolII when the enzyme is already unbound to any other transcription factor, thus avoiding it from contacting DNA outside the promoter. Furthermore, TFIIF stabilizes the RNA polymerase II while it's contacting TBP and TFIIB.

See also


  1. ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. p636–637.  
  2. ^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137.  
  3. ^ Kim TK, Lagrange T, Wang YH, Griffith JD, Reinberg D,  
  4. ^ Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature 355 (6359): 464–7.  
  5. ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4.  
  6. ^ Purrello M, Di Pietro C, Rapisarda A, Mirabile E, Motta S, Sichel G, Grzeschik KH (1995). "Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens". Cytogenet. Cell Genet. 69 (1-2): 75–80.  

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