World Library  
Flag as Inappropriate
Email this Article

Transcription factor II F

Article Id: WHEBN0012589679
Reproduction Date:

Title: Transcription factor II F  
Author: World Heritage Encyclopedia
Language: English
Subject: GTF2F2, RNA polymerase II holoenzyme, NeuroD, EMX homeogene, Nur (biology)
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Transcription factor II F

general transcription factor IIF, polypeptide 1, 74kDa
Identifiers
Symbol GTF2F1
Alt. symbols TFIIF, BTF4, RAP74
Entrez 2962
HUGO 4652
OMIM 189968
RefSeq NM_002096
UniProt P35269
Other data
Locus Chr. 19 p13.3
general transcription factor IIF, polypeptide 2, 30kDa
Identifiers
Symbol GTF2F2
Alt. symbols TFIIF, BTF4, RAP30
Entrez 2963
HUGO 4653
OMIM 189969
RefSeq NM_004128
UniProt P13984
Other data
Locus Chr. 13 q14
general transcription factor IIF, polypeptide 2-like
Identifiers
Symbol GTF2F2L
Alt. symbols TFIIF
Entrez 2964
HUGO 4654
RefSeq NG_003013
Other data
Locus Chr. 4 q31.22

Transcription factor IIF (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1][2][3]

Transcription Factor IIF is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes.[4][5][6]

TFIIF binds to RNA PolII when the enzyme is already unbound to any other transcription factor, thus avoiding it from contacting DNA outside the promoter. Furthermore, TFIIF stabilizes the RNA polymerase II while it's contacting TBP and TFIIB.

See also

References

  1. ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. p636–637.  
  2. ^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137.  
  3. ^ Kim TK, Lagrange T, Wang YH, Griffith JD, Reinberg D,  
  4. ^ Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature 355 (6359): 464–7.  
  5. ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4.  
  6. ^ Purrello M, Di Pietro C, Rapisarda A, Mirabile E, Motta S, Sichel G, Grzeschik KH (1995). "Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens". Cytogenet. Cell Genet. 69 (1-2): 75–80.  

External links


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.