Vamp2

Vesicle-associated membrane protein 2 (synaptobrevin 2)
PDB rendering based on 1kil.
Available structures
PDB Ortholog search: RCSB
Identifiers
VAMP2 Gene
RNA expression pattern

Vesicle-associated membrane protein 2 is a protein that in humans is encoded by the VAMP2 gene.[1][2]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. VAMP2 is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. VAMP2 is thought to participate in neurotransmitter release at a step between docking and fusion. Mice lacking functional synaptobrevin2/VAMP2 gene cannot survive after birth, and have a dramatically reduced synaptic transmission, around 10% of control.[3] The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and complexin. It also forms a distinct complex with synaptophysin.[2]

Interactions

VAMP2 has been shown to interact with STX4,[4][5][6][7] SNAP-25,[8][9][10] SNAP23,[4][11][12] STX1A[9][10][13][14][15][16] and RABAC1.[17]

References

Further reading


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