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Vladimir Prelog

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Vladimir Prelog

Vladimir Prelog
Born (1906-07-23)23 July 1906
Sarajevo, Austria-Hungary
Died 7 January 1998(1998-01-07) (aged 91)
Zürich, Switzerland
Fields Biochemistry
Institutions Czech Institute of Technology
University of Zagreb
ETH Zürich
Alma mater Czech Technical University in Prague (Sc.D, 1929)
Doctoral advisor Emil Votoček
Known for Organic chemistry
Conformational analysis
Cahn-Ingold-Prelog priority rules
Prelog strain
Klyne-Prelog system
Prelog's rule
Influences Robert Robinson
Christopher Ingold
Lavoslav Ružička
Notable awards Marcel Benoist Prize (1964)
Davy Medal (1967)
Paul Karrer Gold Medal (1974)
Nobel Prize for Chemistry (1975)
Spouse Kamila Prelog (née Vitek)

Vladimir Prelog Nobel Prize for chemistry. Prelog was born and grew up in Sarajevo.[2] He lived and worked in Prague, Zagreb and Zürich during his lifetime.[3][4][5][6]


  • Early life 1
    • Education 1.1
  • Career 2
    • Zürich 2.1
  • Nobel Prize 3
  • Yugoslav Academy of Sciences and Arts 4
  • Personal life 5
  • Death 6
  • References 7
  • External links 8

Early life

Prelog was born in Sarajevo, Condominium of Bosnia and Herzegovina, at that time within the Austro-Hungarian Empire, to Croat parents who were working there. His father Milan was a history professor in gymnasium in Sarajevo and later at the University of Zagreb.[7] As a 8-year old boy, he stood near the place where the assassination of Franz Ferdinand occurred.[8]


Prelog attended elementary school in Sarajevo, but in 1915, as a child, Prelog moved to Zagreb (then part of the Kingdom of Croatia-Slavonia) with his parents. In Zagreb he graduated from elementary school. At first, he attended gymnasium in Zagreb, but soon afterwards, his father got a job in Osijek, so he continued his education there. He spent two years in Osijek gymnasium, where he became interested in chemistry under the influence of his professor Ivan Kuria.

In 1922, as a 16-year-old boy, he described a new solution for an analytic instrument in chemical lab for the prominent German scientific magazine

  • Vladimir Prelog
  • Nobel Prize Winners — Vladimir Prelog
  • Croatian Nobel Prize Winners (list),; accessed 29 June 2015.(Croatian)

External links

  • Frängsmyr, Tore; Forsén, Sture (1993). Chemistry, 1971-1980. World Scientific.  
  • James, Laylin K. (2006). Nobel Laureates in Chemistry, 1901-1992. American Chemical Society & Chemical Heritage Foundation.  
  • Rezende, Lisa (2006). Chronology of Science. Infobase Publishing.  
  1. ^  
  2. ^ Vladimir Prelog (1975) Autobiography, the Nobel Committee.
  3. ^ Dunitz, J. D. (1998). "Obituary: Vladimir Prelog (1906–98)". Nature 391 (6667): 542.  
  4. ^ Mislow, K. (2000). "Vladimir Prelog, 23 July 1906 · 7 January 1998". Proceedings of the American Philosophical Society 144 (1): 106–111.  
  5. ^ Kauffman, G. B. (1998). "In Memoriam Vladimir Prelog (1906-1998): Some Personal Reminiscences". The Chemical Educator 3 (2): 1–0.  
  6. ^ Hargittai, I. N.; Hargittai, B. (2006). "Prelog Centennial: Vladimir Prelog (1906–1998)". Structural Chemistry 17: 1.  
  7. ^ a b c d e James 1993, p. 578.
  8. ^ a b Frängsmyr & Forsén 1993, p. 201.
  9. ^ Prelog, V.; Wieland, P. (1944). "Über die Spaltung der Tröger'schen Base in optische Antipoden, ein Beitrag zur Stereochemie des dreiwertigen Stickstoffs". Helvetica Chimica Acta 27: 1127.  
  10. ^ a b c Frängsmyr & Forsén 1993, p. 202.
  11. ^ a b c James 1993, p. 580.
  12. ^ James 1993, p. 580-581.
  13. ^ a b James 1993, p. 581.
  14. ^ Rezende 2006, p. 352.
  15. ^ James 1993, p. 571.
  16. ^ "thefamouspeople.". 
  17. ^ Spomenik Prelogu u Pragu,; accessed 16 May 2015.(Croatian)


Vladimir Prelog died in Zürich, at the age of 91. An urn containing Prelog's ashes was ceremoniously interred at the Mirogoj cemetery in Zagreb on 27 September 2001. In 2008, a memorial to Prelog was unveiled in Prague.[17]


An intellectual with a wide cultural background, Prelog was one of the 109 Nobel Prize winners who signed the peace appeal for Croatia in 1991[16]

In 1933, Prelog married Kamila Vitek.[7] The couple had a son Jan (born 1949).[10]

Personal life

In 1986, he became an honorary member of the Yugoslav Academy of Sciences and Arts.

Yugoslav Academy of Sciences and Arts

[15].John Cornforth research chemist British/Australian sharing it with the [14] Prelog received the 1975

Monument of the Croatian Academy of Sciences and Arts to Franjo Rački, Ivan Miković, Grga Tuškan and Vladimir Prelog in Mirogoj Cemetery

Nobel Prize

Specifying the growing number of R. S. Cahn and Christopher Ingold in their efforts to build a system for specifying a particular stereoisomers by simple and unambiguous descriptors that could be easily assigned and deciphered: The CIP system (Cahn-Ingold-Prelog) was developed for defining absolute configuration using "sequence rules". Together they published two papers. After Cahn and Ingold died, Prelog published a third paper on the topic.[13] In 1959, Prelog obtained Swiss citizenship.[10]

In his research of asymmetric syntheses, Prelog studied enantioselective reactions and established rules for the relationship between configuration of educts and products. From Prelog's researches into the stereospecificity of microbiological reductions of alicyclic ketones and the enzymic oxidation of alcohols, he contributed not only to the knowledge of the mechanism of stereospecificity of enzymic reactions in general but also to the structure of the active site of the enzyme.[13]

In 1944 at the ETH, Prelog managed to separate enantiomers with "asymmetric" trivalent nitrogen by column chromatography at a time when this method was still in its infancy. His work on medium-sized alicyclic and heterocyclic rings established him as a pioneer in stereochemistry and conformational theory and brought an invitation to give the first Centenary Lecture of the Chemical Society in London in 1949. He synthesized medium-sized ring compounds with 8 to 12 members from dicraboxylic acid esters by acyloin condensation and explained their unusual chemical reactivity by a "nonclassical" strain because of energetically unfavorable conformations. He also contributed to the understanding of Bredt's rule by showing that a double bond may occure at the bridgehead if the ring is large enough.[12]

At mid-century, the instrumental revolution necessitated a new approach to structural elucidation. Purely chemical methods had become outdated and had lost some of their intellectual appeal. Recognizing the growing importance of microbial metabolities, Prelog started working on these compounds, which possess unusual structures and interesting biological properties. It led him into antibiotics, and he subsequently elucidated the structures of such compounds as nonactin, boromycin, and rifamycins. For Prelog, natural products represented more than a chemical challenge. He considered them a record of billions of years of evolution.[11]

Prelog's main interest was focused on Robert Robinson's formula for strychnine was not correct. Although the formula he proposed was also not the right one, the discovery increased his international prestige. Later he worked on elucidating the structures of aromatic Erythrina alkaloids with Derek Barton, Oskar Jeger and Robert Burns Woodward.[11]

With this chiral resolution, he was able to prove that not only carbon but also nitrogen atoms can be the chiral centre in a molecule, which had been speculated for several years.[9] His relationship with Ružička helped him climb up the academic hierarchical ladder. Starting as an assistant, he become Privat-Dozent, Titularprofessor, associate professor, and in 1952 full professor. In 1957 he succeeded Ružička as head of the Laboratory.[10] Since Prelog disliked administrative duties, he implemented rotating chairmanship in the ETH.[7] Prelog joined the ETH at the right time, since Ružička's Jewish co-workers left the country and went to the United States, so Prelog filled the vacuum they left.[11]

After World War II broke out, in 1941 Prelog was invited to lecture in Germany by Swiss Federal Institute of Technology (ETH, or Eidgenössische Technische Hochschule). Prelog was able to separate the chiral enantiomers of Tröger's base in 1944 by chromatography on an optically active substrate.


With the help of collaborators and students, and financially sponsored by the pharmaceutical factory "Kaštel" (currently Pliva), he started researching quinine and its compounds. Final work on the industry yielded a financially successful production of Streptazol, one of the first commercial sulfonamides. Scientific work here was crowned with the first synthesis of adamantane, a hydrocarbon with an unusual alicyclic structure, being isolated from Moravian oil fields. The results of Prelog's work have been published in the top European chemical literature and journals.

[7] At [8] Prelog badly wanted to work in academic environment, so he accepted the position of lecturer at the University of Zagreb in 1935.


No academic positions were available because of the Great Depression so instead he started to work in the private plant laboratory of G.J. Dríza in Prague, in charge of the production of rare chemicals that were not available on the market at that time. He worked for Driza from 1929 until 1935. During the time, he got his first doctoral candidate, a company owner Driza. His pastime was spent in his own research, where he started investigating alkaloids from the cacao bark.


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