| V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 |
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| PDB rendering based on 2hda. |
| Available structures |
| PDB |
Ortholog search: RCSB
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| List of PDB id codes |
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2HDA
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| Identifiers |
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| 2.7.10.2 |
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| Gene Ontology |
| Molecular function |
• ion channel binding
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| Cellular component |
• plasma membrane
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| Biological process |
• leukocyte migration
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| Sources: QuickGO |
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| RNA expression pattern |
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Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene.[1][2]
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.[2]
Interactions
YES1 has been shown to interact with Janus kinase 2,[3] CTNND1,[4] RPL10[5] and Occludin.[6]
References
Further reading
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| | ABL family | |
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| | ACK family | |
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| | CSK family | |
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| | FAK family | |
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| | FES family | |
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| | FRK family | |
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| | JAK family | |
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| | SRC-A family | |
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| | SRC-B family | |
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| | TEC family | |
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| | SYK family | |
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