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Title: Yes1  
Author: World Heritage Encyclopedia
Language: English
Subject: Tyrosine kinase, SH2 domain, Transcytosis, Occludin, Janus kinase 2, Non-receptor tyrosine kinase
Publisher: World Heritage Encyclopedia


V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
PDB rendering based on 2hda.
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene.[1][2]

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.[2]


YES1 has been shown to interact with Janus kinase 2,[3] CTNND1,[4] RPL10[5] and Occludin.[6]


Further reading

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