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Yy1

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Title: Yy1  
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Subject: ATF6, Histone deacetylase 2, Histone deacetylase inhibitor, HDAC3, Promoter (genetics)
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Yy1

YY1 transcription factor

PDB rendering based on 1ubd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; DELTA; INO80S; NF-E1; UCRBP; YIN-YANG-1
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

YY1 (Yin Yang 1)[1] is a transcriptional repressor protein in humans that is encoded by the YY1 gene.[2][3] YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.[4]

Contents

  • Interactions 1
  • References 2
  • Further reading 3
  • External links 4

Interactions

YY1 has been shown to interact with Histone deacetylase 2,[5][6][7] FKBP3,[8] ATF6,[9] Myc,[10] SAP30,[11] EP300,[6][12] HDAC3,[5][6] NOTCH1[13] and RYBP.[14]

References

  1. ^ Thiaville, MM; Kim, J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes.". Critical reviews in oncogenesis 16 (3-4): 199–209.  
  2. ^ Shi Y, Seto E, Chang LS, Shenk T (November 1991). "Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein". Cell 67 (2): 377–88.  
  3. ^ Zhu W, Lossie AC, Camper SA, Gumucio DL (July 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mamm Genome 5 (4): 234–6.  
  4. ^ "Entrez Gene: YY1 YY1 transcription factor". 
  5. ^ a b Yang, W M; Yao Y L; Sun J M; Davie J R; Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem. (UNITED STATES) 272 (44): 28001–7.  
  6. ^ a b c Yao, Y L; Yang W M; Seto E (September 2001). "Regulation of Transcription Factor YY1 by Acetylation and Deacetylation". Mol. Cell. Biol. (United States) 21 (17): 5979–91.  
  7. ^ Kalenik, J L; Chen D; Bradley M E; Chen S J; Lee T C (February 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. (ENGLAND) 25 (4): 843–9.  
  8. ^ Yang, W M; Yao Y L; Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J. (England) 20 (17): 4814–25.  
  9. ^ Li, M; Baumeister P; Roy B; Phan T; Foti D; Luo S; Lee A S (July 2000). "ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1". Mol. Cell. Biol. (UNITED STATES) 20 (14): 5096–106.  
  10. ^ Shrivastava, A; Saleque S; Kalpana G V; Artandi S; Goff S P; Calame K (Dec 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc".  
  11. ^ Huang, Nu En; Lin Ching Hui; Lin Young Sun; Yu Winston C Y (June 2003). "Modulation of YY1 activity by SAP30". Biochem. Biophys. Res. Commun. (United States) 306 (1): 267–75.  
  12. ^ Lee, J S; Galvin K M; See R H; Eckner R; Livingston D; Moran E; Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes Dev. (UNITED STATES) 9 (10): 1188–98.  
  13. ^ Yeh, Tien-Shun; Lin Yu-Min; Hsieh Rong-Hong; Tseng Min-Jen (October 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". J. Biol. Chem. (United States) 278 (43): 41963–9.  
  14. ^ García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (June 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. (ENGLAND) 18 (12): 3404–18.  

Further reading

  • Thomas MJ, Seto E (1999). "Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?". Gene 236 (2): 197–208.  
  • Park K, Atchison ML (1991). "Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9804–8.  
  • Yang WM, Inouye CJ, Seto E (1995). "Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity". J. Biol. Chem. 270 (25): 15187–93.  
  • Lee JS, Galvin KM, See RH et al. (1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes Dev. 9 (10): 1188–98.  
  • Zhou Q, Gedrich RW, Engel DA (1995). "Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB". J. Virol. 69 (7): 4323–30.  
  • Shrivastava A, Saleque S, Kalpana GV et al. (1994). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science 262 (5141): 1889–92.  
  • Becker KG, Swergold GD, Ozato K, Thayer RE (1994). "Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element". Hum. Mol. Genet. 2 (10): 1697–702.  
  • Margolis DM, Somasundaran M, Green MR (1994). "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". J. Virol. 68 (2): 905–10.  
  • Lee JS, Galvin KM, Shi Y (1993). "Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6145–9.  
  • Yang WM, Inouye C, Zeng Y et al. (1996). "Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12845–50.  
  • Houbaviy HB, Usheva A, Shenk T, Burley SK (1997). "Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13577–82.  
  • Kalenik JL, Chen D, Bradley ME et al. (1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. 25 (4): 843–9.  
  • Cole EG, Gaston K (1997). "A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors". Nucleic Acids Res. 25 (18): 3705–11.  
  • Yang WM, Yao YL, Sun JM et al. (1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem. 272 (44): 28001–7.  
  • Romerio F, Gabriel MN, Margolis DM (1997). "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF". J. Virol. 71 (12): 9375–82.  
  • McNeil S, Guo B, Stein JL et al. (1998). "Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking". J. Cell. Biochem. 68 (4): 500–10.  
  • Viles JH, Patel SU, Mitchell JB et al. (1998). "Design, synthesis and structure of a zinc finger with an artificial beta-turn". J. Mol. Biol. 279 (4): 973–86.  
  • Yao YL, Dupont BR, Ghosh S et al. (1998). "Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1". Nucleic Acids Res. 26 (16): 3776–83.  

External links

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