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Zona fasciculata

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Title: Zona fasciculata  
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Subject: Adrenal gland, Endocrine system, List of human hormones, Steroid 11-beta-hydroxylase, Adrenocorticotropic hormone
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Zona fasciculata

Zona fasciculata
Layers of adrenaline gland.
Latin Zona fasciculata
Anatomical terminology

The zona fasciculata constitutes the middle zone of the fascicles".

The zona fasciculata chiefly produces glucocorticoids (mainly cortisol in the human), which regulates the metabolism of glucose, especially in times of stress (e.g., part of the fight-or-flight response), it is stimulated by the hormone Adrenocorticotropic Hormone (ACTH) which is released from the anterior portion of the pituitary and axised upon this adrenal gland. This tissue also generates a small amount of weak androgens (e.g., dehydroepiandrosterone). The main source of androgens will come from the zona reticularis region. In certain animals such as rodents, the lack of 17alpha-hydroxylase results in the synthesis of corticosterone instead of cortisol.

Steroid-producing adrenal tumours and hyperplasia of the zona fasciculata result in excess cortisol production and are the cause for adrenal Cushing's syndrome. The genetic disorder McCune-Albright syndrome can also present Cushing's syndrome in affected patients.

adrenal gland (zona fasciculata layer).

External links

  • Histology image: 14502loa – Histology Learning System at Boston University
  • Anatomy Atlases - Microscopic Anatomy, plate 15.292 - "Adrenal Gland"
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