World Library  
Flag as Inappropriate
Email this Article

Zona fasciculata

Article Id: WHEBN0003395303
Reproduction Date:

Title: Zona fasciculata  
Author: World Heritage Encyclopedia
Language: English
Subject: Adrenal gland, Endocrine system, List of human hormones, Steroid 11-beta-hydroxylase, Adrenocorticotropic hormone
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Zona fasciculata

Zona fasciculata
Layers of adrenaline gland.
Details
Latin Zona fasciculata
Dorlands
/Elsevier
z_01/12869721
Anatomical terminology

The zona fasciculata constitutes the middle zone of the fascicles".

The zona fasciculata chiefly produces glucocorticoids (mainly cortisol in the human), which regulates the metabolism of glucose, especially in times of stress (e.g., part of the fight-or-flight response), it is stimulated by the hormone Adrenocorticotropic Hormone (ACTH) which is released from the anterior portion of the pituitary and axised upon this adrenal gland. This tissue also generates a small amount of weak androgens (e.g., dehydroepiandrosterone). The main source of androgens will come from the zona reticularis region. In certain animals such as rodents, the lack of 17alpha-hydroxylase results in the synthesis of corticosterone instead of cortisol.

Steroid-producing adrenal tumours and hyperplasia of the zona fasciculata result in excess cortisol production and are the cause for adrenal Cushing's syndrome. The genetic disorder McCune-Albright syndrome can also present Cushing's syndrome in affected patients.

adrenal gland (zona fasciculata layer).

External links

  • Histology image: 14502loa – Histology Learning System at Boston University
  • Anatomy Atlases - Microscopic Anatomy, plate 15.292 - "Adrenal Gland"
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.