World Library  
Flag as Inappropriate
Email this Article

EDA (gene)

Article Id: WHEBN0014759966
Reproduction Date:

Title: EDA (gene)  
Author: World Heritage Encyclopedia
Language: English
Subject: EDA, Ectoderm, Ectodermal dysplasia, Hypohidrotic ectodermal dysplasia, Tumor necrosis factors, TopoTarget
Publisher: World Heritage Encyclopedia

EDA (gene)

Ectodysplasin A
PDB rendering based on 1rj7.
Available structures
PDB Ortholog search: RCSB
EDA Gene
RNA expression pattern

Ectodysplasin-A is a protein that in humans is encoded by the EDA gene.[1][2]

The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.[2]


Further reading

External links

  • GeneReview/NIH/UW entry on Hypohidrotic Ectodermal Dysplasia

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.