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14-Cinnamoyloxycodeinone

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14-Cinnamoyloxycodeinone

14-Cinnamoyloxycodeinone is the most potent example in a series of opiate analgesic drugs discovered in the 1960s, with > ×100 times the potency of morphine.[1] It is a derivative of hydroxycodeinone, being the 14-cinnamate ester[2]. In another paper, Buckett assigns the potency as 177 with a range (depending on animal and test) of ×101 - ×310[3]. It may be of interest to researchers that the allyl group in this compound and in allylprodine overlay very closely.

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