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Title: Acrasin  
Author: World Heritage Encyclopedia
Language: English
Subject: Cell biology, Cyclic adenosine monophosphate
Publisher: World Heritage Encyclopedia


Each species of slime mold has its own specific chemical messenger, collectively referred to as acrasins. These chemicals signal that lots of individual cells should move towards each other to form a single large cell or plasmodium. One of the earliest acrasins to be identified was cAMP, found in the species Dictyostelium discoideum by Brian Shaffer, which exhibits a complex swirling-pulsating spiral pattern when forming a pseudoplasmodium.

The term acrasin was descriptively named after Acrasia from Edmund Spenser's Faerie Queene, who seduced men against their will and then transformed them into beasts. Acrasia is itself a play on the Greek akrasia that describes loss of free will.


  1. ^ Evidence for the formation of cell aggregates by chemotaxis in the development of the slime mold Dictyostelium discoideum - J.T.Bonner and L.J.Savage Journal of Experimental Biology Vol. 106, pp. 1, October (1947) Cell Biology
  2. ^ Aggregation in cellular slime moulds: in vitro isolation of acrasin - B.M.Shaffer Nature Vol. 79, pp. 975, (1953) Cell Biology
  3. ^ Identification of a pterin as the acrasin of the cellular slime mold Dictyostelium lacteum - Proceedings of the National Academy of Sciences USA Vol. 79, pp. 6270-6274, October (1982) Cell Biology
  4. ^ Hunting Slime Moulds - Adele Conover, Smithsonian Magazine Online (2001)

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