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Title: Bufadienolide  
Author: World Heritage Encyclopedia
Language: English
Subject: Cardiac glycoside
Publisher: World Heritage Encyclopedia


PubChem 3035030
ChemSpider 26286947 YesY
Jmol-3D images Image 1
Molecular formula C24H34O2
Molar mass 354.53 g mol−1
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Bufadienolide is a type of steroid. Its derivatives are collectively known as bufadienolides, including many in the form of bufadienolide glycosides (bufadienolides that contain structural groups derived from sugars). These are a type of cardiac glycoside, the other being the cardenolide glycosides. Both bufadienolides and their glycosides are toxic; specifically, they are heart-arresting.


The term derives from the toad genus Bufo that contains bufadienolide glycosides, the suffix -adien- that refers to the two double bonds in the lactone ring, and the ending -olide that denotes the lactone structure. Consequently, related structures with only one double bond are called bufenolides, and the saturated equivalent is bufanolide.


According to MeSH, bufadienolides and bufanolides are classified as follows:

        • Bufanolides
        • Cardenolides

Note that cardenolides have been classified under cardanolides as well as cardiac glycosides in this classification.

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