World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0013179037
Reproduction Date:

Title: Gpr30  
Author: World Heritage Encyclopedia
Language: English
Subject: Estrogen, Integral membrane protein, Estriol, Steroid hormone receptor, Estrogen receptor, Sex hormone receptor
Publisher: World Heritage Encyclopedia


G protein-coupled estrogen receptor 1
RNA expression pattern

G protein-coupled estrogen receptor 1 (GPER) also known as the G protein-coupled receptor 30 (GPR30) is a G protein-coupled receptor that in humans is encoded by the GPER gene.[1] GPR30 is an integral membrane protein with high affinity for estrogen.[2][3][4][5]


This protein is a member of the rhodopsin-like family of G protein-coupled receptors and is a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants that encode the same protein have been characterized.[6] The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary.[7]

Animal studies

Female GPR30 knockout mice display hyperglycemia and impaired glucose tolerance, reduced body growth, and increased blood pressure.[8] Male GPR30 knockout mice are observed to have increased growth, body fat, increased osteoblast function (mineralization) resulting in higher bone mineral density and trabecular bone volume, and persistent growth plate activity resulting in longer bones.[9]

Clinical significance

GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells.[10]


Further reading

External links

  • Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.