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Glycoprotein IX

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Title: Glycoprotein IX  
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Subject: Glycoprotein Ib, Platelet membrane glycoprotein, GP1BA, ITGA2B, GP1BB
Collection: Clusters of Differentiation
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Glycoprotein IX

Glycoprotein IX (platelet)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CD42a; GPIX
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.[1] Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400) (known as the Glycoprotein Ib-IX-V Receptor Complex). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511).[supplied by OMIM][1]

Contents

  • See also 1
  • References 2
  • Further reading 3
  • External links 4

See also

References

  1. ^ a b "Entrez Gene: GP9 glycoprotein IX (platelet)". 

Further reading

  • Kunishima S, Kamiya T, Saito H (2003). "Genetic abnormalities of Bernard-Soulier syndrome". Int. J. Hematol. 76 (4): 319–27.  
  • Hickey MJ, Deaven LL, Roth GJ (1991). "Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3". FEBS Lett. 274 (1–2): 189–92.  
  • Du X, Beutler L, Ruan C, et al. (1987). "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood 69 (5): 1524–7.  
  • Andrews RK, Booth WJ, Gorman JJ, et al. (1990). "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex". Biochemistry 28 (21): 8317–26.  
  • Hickey MJ, Williams SA, Roth GJ (1989). "Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures". Proc. Natl. Acad. Sci. U.S.A. 86 (17): 6773–7.  
  • Roth GJ, Ozols J, Nugent DJ, Williams SA (1988). "Isolation and characterization of human platelet glycoprotein IX". Biochem. Biophys. Res. Commun. 156 (2): 931–9.  
  • Meyer SC, Fox JE (1995). "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells". J. Biol. Chem. 270 (24): 14693–9.  
  • Clemetson JM, Kyrle PA, Brenner B, Clemetson KJ (1994). "Variant Bernard-Soulier syndrome associated with a homozygous mutation in the leucine-rich domain of glycoprotein IX". Blood 84 (4): 1124–31.  
  • Hickey MJ, Roth GJ (1993). "Characterization of the gene encoding human platelet glycoprotein IX". J. Biol. Chem. 268 (5): 3438–43.  
  • Wright SD, Michaelides K, Johnson DJ, et al. (1993). "Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome". Blood 81 (9): 2339–47.  
  • Berger G, Massé JM, Cramer EM (1996). "Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V". Blood 87 (4): 1385–95.  
  • Hollmann C, Haag F, Schlott M, et al. (1996). "Molecular characterization of mouse T-cell ecto-ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products". Mol. Immunol. 33 (9): 807–17.  
  • Noris P, Simsek S, Stibbe J, von dem Borne AE (1997). "A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome". Br. J. Haematol. 97 (2): 312–20.  
  • Hayashi T, Suzuki K, Yahagi A, et al. (1997). "Corrected DNA sequence of the platelet glycoprotein IX gene". Thromb. Haemost. 77 (5): 1034–5.  
  • Bradford HN, Dela Cadena RA, Kunapuli SP, et al. (1997). "Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex". Blood 90 (4): 1508–15.  
  • Suzuki K, Hayashi T, Yahagi A, et al. (1998). "Novel point mutation in the leucine-rich motif of the platelet glycoprotein IX associated with Bernard-Soulier syndrome". Br. J. Haematol. 99 (4): 794–800.  
  • Noris P, Arbustini E, Spedini P, et al. (1999). "A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV". Br. J. Haematol. 103 (4): 1004–13.  
  • Longhurst CM, White MM, Wilkinson DA, Jennings LK (1999). "A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states". Eur. J. Biochem. 263 (1): 104–11.  
  • Kunishima S, Tomiyama Y, Honda S, et al. (2000). "Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome". Br. J. Haematol. 107 (3): 539–45.  
  • Rivera CE, Villagra J, Riordan M, et al. (2001). "Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome". Br. J. Haematol. 112 (1): 105–8.  

External links

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