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Hla-doa

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Hla-doa

Major histocompatibility complex, class II, DO alpha
Available structures
PDB Ortholog search: RCSB
Identifiers
HLA-DOA Gene
RNA expression pattern

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.[1][2]

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.[2]

References

Further reading


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