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Title: Lymphotoxin  
Author: World Heritage Encyclopedia
Language: English
Subject: List of MeSH codes (D12.644), Outline of immunology, Lymphotoxin alpha, Tumor necrosis factor alpha, Tumor necrosis factors
Publisher: World Heritage Encyclopedia


lymphotoxin alpha (TNF superfamily, member 1)
Symbol LTA
Alt. symbols TNFB
Entrez 4049
HUGO 6709
OMIM 153440
RefSeq NM_000595
UniProt P01374
Other data
Locus Chr. 6 p21.3
lymphotoxin beta (TNF superfamily, member 3)
Symbol LTB
Alt. symbols TNFC
Entrez 4050
HUGO 6711
OMIM 600978
RefSeq NM_002341
UniProt Q06643
Other data
Locus Chr. 6 p21.3

Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine.

It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them.[1] It is also known to be required for normal development of Peyer's patches.[2]

Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs.

See also


  1. ^ Parham, Peter (2005). "Chapter 6: T-cell mediated immunity". The immune system (2nd ed.). New York: Garland Science. p. 172.  
  2. ^ Kumar. "Chapter 13 – Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus". In Kumar. Robbins and Cotran Pathologic Basis of Disease, Professional Edition (8th ed.). 

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